An unusual cause of paraesthesia in a neo-adjuvant gastro-oesophageal cancer.
Adenocarcinoma
/ therapy
Antineoplastic Agents
/ adverse effects
Aorta, Thoracic
Cisplatin
/ adverse effects
Combined Modality Therapy
Diagnosis, Differential
Esophageal Neoplasms
/ therapy
Female
Humans
Iliac Artery
Middle Aged
Neoadjuvant Therapy
Paresthesia
/ chemically induced
Thromboembolism
/ chemically induced
Tomography, X-Ray Computed
cancer intervention
oesophageal cancer
oncology
radiology
venous thromboembolism
Journal
BMJ case reports
ISSN: 1757-790X
Titre abrégé: BMJ Case Rep
Pays: England
ID NLM: 101526291
Informations de publication
Date de publication:
22 Aug 2019
22 Aug 2019
Historique:
entrez:
25
8
2019
pubmed:
25
8
2019
medline:
7
2
2020
Statut:
epublish
Résumé
There is ongoing debate about the best neo-adjuvant strategy for localised resectable oesophageal cancer, however chemotherapy is often employed. Both oesophageal cancer and cisplatin carry an increased risk of thrombosis. Here, we look at an unusual finding in a previously fit woman who presented following neo-adjuvant chemotherapy for resectable oesophageal cancer with increasing difficulty in walking and lower limb paraesthesia. This case looks particularly at the diagnostic challenge and concerns raised in a patient undergoing radical treatment as well as the challenge of complications secondary to treatment with chemotherapy. Willingness to reassess and revisit is a vital part of the diagnostic process. Vascular complications of a disease can be notorious to diagnose and, as in this case can mimic arguably more logical diagnoses. Cancer care provides the unique challenge of investigating unusual presentations related both to disease and treatment.
Identifiants
pubmed: 31444258
pii: 12/8/e225450
doi: 10.1136/bcr-2018-225450
pmc: PMC6721004
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Cisplatin
Q20Q21Q62J
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Thromb Haemost. 2017 Oct 5;117(10):1952-1961
pubmed: 28837207
J Urol. 2016 Jan;195(1):33-40
pubmed: 26341576
Curr Oncol. 2011 Apr;18(2):e97-e100
pubmed: 21505594
J Clin Oncol. 2011 May 1;29(13):1715-21
pubmed: 21444866
Adv Clin Chem. 2018;85:71-89
pubmed: 29655462
Cancer. 1993 Jul 15;72(2):587-93
pubmed: 8319192
J Clin Oncol. 2009 Aug 10;27(23):3786-93
pubmed: 19398575
Intern Med. 2019 Feb 1;58(3):381-385
pubmed: 30210102
Lancet Oncol. 2016 Dec;17(12):1697-1708
pubmed: 27776843
Lancet. 2019 May 11;393(10184):1948-1957
pubmed: 30982686