Protozoan persister-like cells and drug treatment failure.
Antiprotozoal Agents
/ pharmacology
Biological Variation, Population
Chagas Disease
/ drug therapy
Drug Tolerance
Humans
Leishmania
/ drug effects
Leishmaniasis
/ drug therapy
Malaria
/ drug therapy
Plasmodium
/ drug effects
Toxoplasma
/ drug effects
Toxoplasmosis
/ drug therapy
Treatment Failure
Trypanosoma cruzi
/ drug effects
Journal
Nature reviews. Microbiology
ISSN: 1740-1534
Titre abrégé: Nat Rev Microbiol
Pays: England
ID NLM: 101190261
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
accepted:
03
07
2019
pubmed:
25
8
2019
medline:
4
3
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
Antimicrobial treatment failure threatens our ability to control infections. In addition to antimicrobial resistance, treatment failures are increasingly understood to derive from cells that survive drug treatment without selection of genetically heritable mutations. Parasitic protozoa, such as Plasmodium species that cause malaria, Toxoplasma gondii and kinetoplastid protozoa, including Trypanosoma cruzi and Leishmania spp., cause millions of deaths globally. These organisms can evolve drug resistance and they also exhibit phenotypic diversity, including the formation of quiescent or dormant forms that contribute to the establishment of long-term infections that are refractory to drug treatment, which we refer to as 'persister-like cells'. In this Review, we discuss protozoan persister-like cells that have been linked to persistent infections and discuss their impact on therapeutic outcomes following drug treatment.
Identifiants
pubmed: 31444481
doi: 10.1038/s41579-019-0238-x
pii: 10.1038/s41579-019-0238-x
pmc: PMC7024564
mid: NIHMS1556717
doi:
Substances chimiques
Antiprotozoal Agents
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
607-620Subventions
Organisme : Medical Research Council
ID : MR/S019650/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI124692
Pays : United States
Organisme : Medical Research Council
ID : MR/L018853/1
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI164473
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI144591
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI109530
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI118426
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI034036
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
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