Clinically feasible method for assessing leukocyte rheology in whole blood.
Acute Coronary Syndrome
/ blood
Adult
Aged
Biomarkers
/ blood
Blood Flow Velocity
Case-Control Studies
Cell Adhesion
Diabetes Mellitus, Type 2
/ blood
Feasibility Studies
Female
Hemorheology
Humans
Kinetics
Lab-On-A-Chip Devices
Leukocytes
/ metabolism
Male
Microcirculation
Microfluidic Analytical Techniques
/ instrumentation
Middle Aged
Peroxidase
/ blood
Predictive Value of Tests
Rheology
Acute coronary syndrome
Diabetes mellitus
Leukocyte
Microcirculation
Rheology
Journal
Heart and vessels
ISSN: 1615-2573
Titre abrégé: Heart Vessels
Pays: Japan
ID NLM: 8511258
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
07
05
2019
accepted:
16
08
2019
pubmed:
25
8
2019
medline:
27
10
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
This study reports a novel method for assessment of leukocyte rheological activation with a new designed microchannel array chip to mimic the human microvascular network for microchannel array flow analysis (MCFAN). Study subjects were 79 healthy volunteers and 42 patients with type 2 diabetes mellitus (DM) and 36 patients with acute coronary syndrome (ACS). Using the anticoagulants heparin and ethylene-diamine-tetraacetic acid (EDTA)-2Na which inhibits platelets and leukocytes by chelating Ca
Identifiants
pubmed: 31444563
doi: 10.1007/s00380-019-01486-y
pii: 10.1007/s00380-019-01486-y
pmc: PMC6981318
doi:
Substances chimiques
Biomarkers
0
MPO protein, human
EC 1.11.1.7
Peroxidase
EC 1.11.1.7
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
268-277Subventions
Organisme : a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : 23500590
Organisme : a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan
ID : 26350581
Organisme : the Vehicle Racing Commemorative Foundation
ID : none
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