Understanding biochemical processes in the presence of sub-diffusive behavior of biomolecules in solution and living cells.
Anomalous diffusion
Biological functions
Conformational equilibria
Gene expression
Macromolecular crowding
Protein stability
Protein–protein interaction
Journal
Biophysical reviews
ISSN: 1867-2450
Titre abrégé: Biophys Rev
Pays: Germany
ID NLM: 101498573
Informations de publication
Date de publication:
Dec 2019
Dec 2019
Historique:
received:
03
07
2019
accepted:
25
07
2019
pubmed:
25
8
2019
medline:
25
8
2019
entrez:
25
8
2019
Statut:
ppublish
Résumé
In order to maintain cellular function, biomolecules like protein, DNA, and RNAs have to diffuse to the target spaces within the cell. Changes in the cytosolic microenvironment or in the nucleus during the fulfillment of these cellular processes affect their mobility, folding, and stability thereby impacting the transient or stable interactions with their adjacent neighbors in the organized and dynamic cellular interior. Using classical Brownian motion to elucidate the diffusion behavior of these biomolecules is hard considering their complex nature. The understanding of biomolecular diffusion inside cells still remains elusive due to the lack of a proper model that can be extrapolated to these cases. In this review, we have comprehensively addressed the progresses in this field, laying emphasis on the different aspects of anomalous diffusion in the different biochemical reactions in cell interior. These experiment-based models help to explain the diffusion behavior of biomolecules in the cytosolic and nuclear microenvironment. Moreover, since understanding of biochemical reactions within living cellular system is our main focus, we coupled the experimental observations with the concept of sub-diffusion from in vitro to in vivo condition. We believe that the pairing between the understanding of complex behavior and structure-function paradigm of biological molecules would take us forward by one step in order to solve the puzzle around diseases caused by cellular dysfunction.
Identifiants
pubmed: 31444739
doi: 10.1007/s12551-019-00580-9
pii: 10.1007/s12551-019-00580-9
pmc: PMC6957588
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
851-872Références
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