Primary pancreatic diffuse large B-cell lymphoma diagnosed by endoscopic ultrasound guided FNAC: A rare entity.
diffuse large B-cell lymphoma
endoscopic ultrasound guided
fine-needle aspiration
non-Hodgkin lymphoma
primary pancreatic lymphoma
Journal
Diagnostic cytopathology
ISSN: 1097-0339
Titre abrégé: Diagn Cytopathol
Pays: United States
ID NLM: 8506895
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
04
06
2019
revised:
28
07
2019
accepted:
30
07
2019
pubmed:
25
8
2019
medline:
5
6
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
Primary pancreatic lymphoma (PPL) is an uncommon neoplasm which can clinico-radiologically mimic carcinoma. But the management of these patients differs from that of a carcinoma. Endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) serves as a potential tool to identify pancreatic lymphomas and thus prevent an invasive diagnostic test. This case report describes the presentation and diagnosis of primary pancreatic lymphoma. A 37-year-old female presented with nausea, vomiting with signs of icterus and elevated liver function test and Bilirubin. Abdominal computed tomography (CT) revealed a hypodense lesion in the head of the pancreas. EUS guided FNA was performed and cytological material was collected. The lesion was diagnosed as Non-Hodgkin Lymphoma (NHL) and subtyped as diffuse large B-cell lymphoma-germinal centre (DLBCL-GCB) base on immunohistochemistry on cell block. The patient was started on rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (RCHOP) regimen. EUS guided FNA along with ROSE, cell bock, and immunocytochemistry helps in the diagnosis of primary pancreatic lymphoma.
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
57-60Informations de copyright
© 2019 Wiley Periodicals, Inc.
Références
Sadaf S, Loya A, Akhtar N, Yusuf MA. Role of endoscopic ultrasound-guided-fine needle aspiration biopsy in the diagnosis of lymphoma of the pancreas: a clinicopathological study of nine cases. Cytopathology. 2017;28:536-541.
Nayer H, Weir EG, Sheth S, Ali SZ. Primary pancreatic lymphomas: a cytopathologic analysis of a rare malignancy. Cancer. 2004;102:315-321.
Yu L, Chen Y, Xing L. Primary pancreatic lymphoma: two case reports and a literature review. OncoTargets Therapy. 2017;10:1687-1694.
Primary pancreatic lymphoma, a case report and review of literature. Austin J Med Oncol. 2015;2:1-4.
Krol ADG, le Cessie S, Snijder S, Kluin-Nelemans JC, Kluin PM, Noordijk EM. Primary extranodal non-Hodgkin's lymphoma (NHL): the impact of alternative definitions tested in the comprehensive cancer Centre West population-based NHL registry. Ann Oncol. 2003;14:131-139.
Papaxoinis G, Papageorgiou S, Rontogianni D, et al. Primary gastrointestinal non-Hodgkin's lymphoma: a clinicopathologic study of 128 cases in Greece. A Hellenic cooperative oncology group study (HeCOG). Leuk Lymphoma. 2006;47:2140-2146.
López-Guillermo A, Colomo L, Jiménez M, et al. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. J Clin Oncol. 2005;23:2797-2804.
Behrns KE, Sarr MG, Strickler JG. Pancreatic lymphoma: is it a surgical disease. Pancreas. 1994;9:662-667.
Volmar KE, Routbort MJ, Jones CK, Xie HB. Primary pancreatic lymphoma evaluated by fine-needle AspirationFindings in 14 cases. Am J Clin Pathol. 2004;121:898-903.
Liakakos T, Misiakos EP, Tsapralis D, Nikolaou I, Karatzas G, Macheras A. A role for surgery in primary pancreatic B-cell lymphoma: a case report. J Med Case Reports. 2008;2:167.
Grimison PS, Chin MT, Harrison ML, Goldstein D. Primary pancreatic lymphoma - pancreatic tumours that are potentially curable without resection, a retrospective review of four cases. BMC Cancer. 2006;6:117.
Ohnishi Y, Akashi T, Kuniyoshi M, et al. A case of adult T cell leukemia (lymphoma type) involving the pancreas. The Japanese Journal of Gastroenterology. 1999;96:64-69.
Maruyama H, Nakatsuji N, Sugihara S, et al. Anaplastic Ki-1-positive large cell lymphoma of the pancreas: a case report and review of the literature. Jpn J Clin Oncol. 1997;27:51-57.
Hans CP, Weisenburger DD, Greiner TC, et al. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Blood. 2004;103:275-282.