Perfluorooctanoic acid-induced toxicities in chicken embryo primary cardiomyocytes: Roles of PPAR alpha and Wnt5a/Frizzled2.

Animals Calcium / metabolism Caprylates / toxicity Cardiotoxicity Cells, Cultured Chick Embryo Environmental Pollutants / toxicity Fluorocarbons / toxicity Frizzled Receptors / metabolism Myocytes, Cardiac / drug effects PPAR alpha / metabolism Signal Transduction / drug effects Wnt-5a Protein / metabolism
Perfluorooctanoic acid Wnt5a/Frizzled2 in ovo gene silencing intracellular calcium primary cardiomyocyte

Journal

Toxicology and applied pharmacology
ISSN: 1096-0333
Titre abrégé: Toxicol Appl Pharmacol
Pays: United States
ID NLM: 0416575

Informations de publication

Date de publication:
15 10 2019
Historique:
received: 28 05 2019
revised: 25 07 2019
accepted: 18 08 2019
pubmed: 25 8 2019
medline: 19 5 2020
entrez: 25 8 2019
Statut: ppublish

Résumé

Perfluorooctanoic acid (PFOA) is a widespread persistent organic pollutant and may induce developmental toxicities, including developmental cardiotoxicity. To explore the potential mechanism of developmental cardiotoxicity induced by PFOA exposure, chicken embryo primary cardiomyocytes were extracted either from chicken embryos pretreated with PFOA (2 mg/kg), or from untreated embryos and then directly exposed cells to PFOA (1, 10, 30 or 100 μg/ml) in culture. Additionally, peroxisome proliferator activated receptor alpha (PPAR alpha) silencing lentivirus was applied to the embryos on embryonic day (ED2). Cell viability was measured with CCK-8 kit, morphology was assessed with hematoxylin and eosin staining, and intracellular Ca

Identifiants

DOI: 10.1016/j.taap.2019.114716 PMID: 31445018
pubmed: 31445018
pii: S0041-008X(19)30324-2
doi: 10.1016/j.taap.2019.114716
pii:
doi:

Substances chimiques

Caprylates 0
Environmental Pollutants 0
Fluorocarbons 0
Frizzled Receptors 0
PPAR alpha 0
Wnt-5a Protein 0
perfluorooctanoic acid 947VD76D3L
Calcium SY7Q814VUP

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

114716

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Na Lv (N)

Department of Pharmacology, School of Pharmacy, Qingdao University, China.

Junhua Yuan (J)

Department of Special Medicine, School of Basic Medicine, Qingdao University, China.

Andong Ji (A)

Department of Toxicology, School of Public Health, Qingdao University, China.

Limei Shi (L)

Department of Toxicology, School of Public Health, Qingdao University, China.

Mengyu Gao (M)

Department of Toxicology, School of Public Health, Qingdao University, China.

Lianhua Cui (L)

Department of Toxicology, School of Public Health, Qingdao University, China.

Qixiao Jiang (Q)

Department of Toxicology, School of Public Health, Qingdao University, China. Electronic address: jiangq@qdu.edu.cn.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Lipides › Acides gras › Caprylates › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Cardiotoxicité › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Cellules › Cellules cultivées › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › Embryon de poulet › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures halogénés › Hydrocarbures fluorés › Fluorocarbones › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs Wnt › Récepteurs Frizzled › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteur PPAR alpha › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Perfluorooctanoic acid-induced toxicities in...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Protéines de type Wingless › Protéine Wnt-5a › Perfluorooctanoic acid-induced toxicities in...