Retinal vascular fractal dimension in bipolar disorder and schizophrenia.
Bipolar disorder
Fractal dimension
Fundus
Neurodevelopment
Psychoses
Retinal vasculature
Schizophrenia
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
01 12 2019
01 12 2019
Historique:
received:
26
03
2019
revised:
14
06
2019
accepted:
18
08
2019
pubmed:
25
8
2019
medline:
21
7
2020
entrez:
25
8
2019
Statut:
ppublish
Résumé
Bipolar disorder (BD) and schizophrenia (SCZ), are associated with greater vascular co-morbidities and adverse vascular events. Owing to shared developmental origins and morphology, retinal vasculature is a proxy assessment measure of the cerebral vasculature. Although retinal vascular fractal dimension (D We studied 277 participants (92 healthy volunteers, 98 SCZ, and 87 BD) from 18 to 50 years of age. Images were acquired by trained personnel using a non-mydriatic fundus camera and the retinal vascular D Both SCZ and BD had significantly increased D The study design was cross-sectional, and patients were on medications. Confound of lifestyle factors such as diet and exercise, if any, was not controlled. Sub-group analysis between BD-I and BD-II was not performed in view of the small sample. Considering the easy accessibility, affordability, and non-invasive nature of the examination, retinal vascular D
Sections du résumé
BACKGROUND
Bipolar disorder (BD) and schizophrenia (SCZ), are associated with greater vascular co-morbidities and adverse vascular events. Owing to shared developmental origins and morphology, retinal vasculature is a proxy assessment measure of the cerebral vasculature. Although retinal vascular fractal dimension (D
METHODS
We studied 277 participants (92 healthy volunteers, 98 SCZ, and 87 BD) from 18 to 50 years of age. Images were acquired by trained personnel using a non-mydriatic fundus camera and the retinal vascular D
RESULTS
Both SCZ and BD had significantly increased D
LIMITATIONS
The study design was cross-sectional, and patients were on medications. Confound of lifestyle factors such as diet and exercise, if any, was not controlled. Sub-group analysis between BD-I and BD-II was not performed in view of the small sample.
CONCLUSIONS
Considering the easy accessibility, affordability, and non-invasive nature of the examination, retinal vascular D
Identifiants
pubmed: 31445346
pii: S0165-0327(19)30755-4
doi: 10.1016/j.jad.2019.08.061
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
98-103Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.