Cellular regeneration of podocytes from parietal cells: the debate is still open.

Animals Epithelial Cells Glomerulosclerosis, Focal Segmental Kidney Glomerulus Mice Podocytes Regeneration

Journal

Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470

Informations de publication

Date de publication:
09 2019
Historique:
received: 08 04 2019
accepted: 23 04 2019
entrez: 26 8 2019
pubmed: 26 8 2019
medline: 13 6 2020
Statut: ppublish

Résumé

The study by Kaverina et al. in this issue addresses an important question: can podocytes be replenished by parietal epithelial cells (PECs)? The authors use a complex transgenic mouse model in which podocytes are labeled with GFP and PECs are simultaneously labeled with tdTomato. When Kaverina and colleagues induce focal segmental glomerulosclerosis (FSGS), they find that individual PECs are doubly labeled, coexpress podocyte markers, and form structures similar to foot processes, suggesting that these PECs may have transdifferentiated into podocytes.

Identifiants

DOI: 10.1016/j.kint.2019.04.038 PMID: 31445579
pubmed: 31445579
pii: S0085-2538(19)30521-6
doi: 10.1016/j.kint.2019.04.038
pii:
doi:

Types de publication

Journal Article Comment

Langues

eng

Sous-ensembles de citation

IM

Pagination

542-544

Commentaires et corrections

Type : CommentOn

Informations de copyright

Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.

Auteurs

Marcus J Moeller (MJ)

Division of Nephrology and Clinical Immunology, Rheinisch-Westfälische Technische Hochschule (RWTH) Aachen University, Aachen, Germany. Electronic address: mmoeller@ukaachen.de.

Pierre-Louis Tharaux (PL)

Université; de Paris, Paris Cardiovascular Centre PARCC, Institut National de la Santé et de la Recherche Médicale (INSERM), Paris, France.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Cellular regeneration of podocytes from...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellular regeneration of podocytes from...
questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Néphrite › Glomérulonéphrite › Glomérulonéphrite segmentaire et focale › Cellular regeneration of podocytes from...
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › Néphrons › Glomérule rénal › Cellular regeneration of podocytes from...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Cellular regeneration of podocytes from...
questionsmedicales.fr › Cellules › Cellules épithéliales › Podocytes › Cellular regeneration of podocytes from...
questionsmedicales.fr › Phénomènes biologiques › Régénération › Cellular regeneration of podocytes from...