Radiation-induced redox alteration in the mouse brain.

Animals Brain / pathology Carbon / adverse effects Contrast Media / chemistry Cranial Irradiation / adverse effects Cyclic N-Oxides / chemistry Female Magnetic Resonance Imaging / methods Mice Mice, Inbred C3H Nitrogen Oxides / chemistry Oxidation-Reduction Oxidative Stress Spin Labels X-Rays
Carbon ion beam Mouse brain Redox imaging Redox-sensitive contrast agent Tissue redox status X-ray

Journal

Free radical biology & medicine
ISSN: 1873-4596
Titre abrégé: Free Radic Biol Med
Pays: United States
ID NLM: 8709159

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 17 06 2019
revised: 20 08 2019
accepted: 20 08 2019
pubmed: 26 8 2019
medline: 23 7 2020
entrez: 26 8 2019
Statut: ppublish

Résumé

Time courses of the redox status in the brains of mice after X-ray or carbon-ion beam irradiation were observed by magnetic resonance redox imaging (MRRI). The relationship between radiation-induced oxidative stress on the cerebral nervous system and the redox status in the brain was discussed. The mice were irradiated by 8-Gy X-ray or carbon-ion beam (C-beam) on their head under anesthesia. C-beam irradiation was performed at HIMAC (Heavy-Ion Medical Accelerator in Chiba, NIRS/QST, Chiba, Japan). MRRI measurements using a blood-brain-barrier-permeable nitroxyl contrast agent, MCP or TEMPOL, were performed using 7-T scanner at several different times, i.e., 5-10 h, 1, 2, 4, and 8 day(s) after irradiation. Decay rates of the nitroxyl-enhanced T

Identifiants

DOI: 10.1016/j.freeradbiomed.2019.08.020 PMID: 31446055
pubmed: 31446055
pii: S0891-5849(19)30991-8
doi: 10.1016/j.freeradbiomed.2019.08.020
pii:
doi:

Substances chimiques

Contrast Media 0
Cyclic N-Oxides 0
Nitrogen Oxides 0
Spin Labels 0
Carbon 7440-44-0
nitroxyl GFQ4MMS07W
tempol U78ZX2F65X

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

412-421

Informations de copyright

Copyright © 2019 Elsevier Inc. All rights reserved.

Auteurs

Mizuki Nakamura (M)

Quantitative RedOx Sensing Group, Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan; Graduate School of Medical and Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-88670, Japan.

Toshihide Yamasaki (T)

Laboratory of Biophysical Chemistry, Kobe Pharmaceutical University, 4-19-1 Motoyama-kita, Higashinada, Kobe, 658-8558, Japan.

Megumi Ueno (M)

Quantitative RedOx Sensing Group, Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan.

Sayaka Shibata (S)

Preclinical Research and Development for Functional and Molecular Imaging Group, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.

Yoshikazu Ozawa (Y)

Preclinical Research and Development for Functional and Molecular Imaging Group, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.

Tadashi Kamada (T)

Graduate School of Medical and Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-88670, Japan; Research Center Hospital, Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.

Ikuo Nakanishi (I)

Quantitative RedOx Sensing Group, Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan; Institute for Quantum Life Science (iQLS), National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.

Ken-Ichi Yamada (KI)

Physical Chemistry for Life Science Laboratory, Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka, 812-8582, Japan; JST, PRESTO, 4-1-8 Honcho, Kawaguchi, Saitama, 332-0012, Japan.

Ichio Aoki (I)

Preclinical Research and Development for Functional and Molecular Imaging Group, Department of Molecular Imaging and Theranostics, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan; Institute for Quantum Life Science (iQLS), National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan.

Ken-Ichiro Matsumoto (KI)

Quantitative RedOx Sensing Group, Department of Basic Medical Sciences for Radiation Damages, National Institute of Radiological Sciences, Quantum Medical Science Directorate, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba-shi, Chiba, 263-8555, Japan; Institute for Quantum Life Science (iQLS), National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, 263-8555, Japan. Electronic address: matsumoto.kenichiro@qst.go.jp.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Produits chimiques inorganiques › Éléments › Carbone › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Thérapeutique › Radiothérapie › Irradiation crânienne › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Composés hétérocycliques › Oxydes hétérocycliques › N-oxydes cycliques › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C3H › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Composés chimiques organiques › Radicaux libres › Marqueurs de spin › Radiation-induced redox alteration in the mouse brain.
questionsmedicales.fr › Phénomènes physiques › Rayonnement › Rayonnement ionisant › Rayons X › Radiation-induced redox alteration in the mouse brain.