Ultrasonographic evaluation of the diaphragm thickness in patients with multiple sclerosis.
Diaphragm
Multiple sclerosis
Ultrasonography
Ultrasound
Journal
Multiple sclerosis and related disorders
ISSN: 2211-0356
Titre abrégé: Mult Scler Relat Disord
Pays: Netherlands
ID NLM: 101580247
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
24
06
2019
revised:
22
07
2019
accepted:
11
08
2019
pubmed:
26
8
2019
medline:
20
5
2020
entrez:
26
8
2019
Statut:
ppublish
Résumé
Diaphragm weakness or dysfunction have been previously reported in multiple sclerosis (MS) patients. The aim of this study was to evaluate diaphragm thickness and thickenning ratio (TR) using ultrasound in MS patients. This prospective study comprised MS patients and a control group. Ultrasound examination was performed using a linear transducer (6-15 MHz). The diaphragm was seen as a hypoechoic structre between the peritoneum and pleura. End-expirium and end-inspirium measurements were obtained. Change levels and TR (%) were calculated. All participants were assessed using the Expanded Distability Status Scale (EDSS) and Fatigue Severity Scale (FSS). Evaluation was made of 45 MS patients (11 males, 34 females) with a mean age of 37.36±9.0 years and 36 healthy subjects (3 males, 33 females) with a mean age of 35.19±9.3 years. The diaphragm thicknesses were similar at end-expirium (1.86±0.3 vs. 1.83±0.3 mm) and end-inspirium (3.14±0.6 vs. 3.46±0.6 mm). The change level with inspirium (0.90±0.6 vs. 1.31±0.7 mm) and TR (49.77±37.7 vs. 72.30±40.1%) were significantly higher in the control group compared to the values of MS patients. A weak and negative correlation was determined between EDSS and TR values (r=-0.293, p = 0.008), and no significant correlation was observed between the FSS values and diaphragm thickness (p>0.05 for all). Although the diaphragm thickness of MS patients seems to be similar to those of healthy subjects, the change level and TR of MS patients seem to be lower. Furthermore, the change level and TR were found to be associated with EDSS.
Sections du résumé
BACKGROUND
BACKGROUND
Diaphragm weakness or dysfunction have been previously reported in multiple sclerosis (MS) patients. The aim of this study was to evaluate diaphragm thickness and thickenning ratio (TR) using ultrasound in MS patients.
METHODS
METHODS
This prospective study comprised MS patients and a control group. Ultrasound examination was performed using a linear transducer (6-15 MHz). The diaphragm was seen as a hypoechoic structre between the peritoneum and pleura. End-expirium and end-inspirium measurements were obtained. Change levels and TR (%) were calculated. All participants were assessed using the Expanded Distability Status Scale (EDSS) and Fatigue Severity Scale (FSS).
RESULTS
RESULTS
Evaluation was made of 45 MS patients (11 males, 34 females) with a mean age of 37.36±9.0 years and 36 healthy subjects (3 males, 33 females) with a mean age of 35.19±9.3 years. The diaphragm thicknesses were similar at end-expirium (1.86±0.3 vs. 1.83±0.3 mm) and end-inspirium (3.14±0.6 vs. 3.46±0.6 mm). The change level with inspirium (0.90±0.6 vs. 1.31±0.7 mm) and TR (49.77±37.7 vs. 72.30±40.1%) were significantly higher in the control group compared to the values of MS patients. A weak and negative correlation was determined between EDSS and TR values (r=-0.293, p = 0.008), and no significant correlation was observed between the FSS values and diaphragm thickness (p>0.05 for all).
CONCLUSION
CONCLUSIONS
Although the diaphragm thickness of MS patients seems to be similar to those of healthy subjects, the change level and TR of MS patients seem to be lower. Furthermore, the change level and TR were found to be associated with EDSS.
Identifiants
pubmed: 31446243
pii: S2211-0348(19)30338-4
doi: 10.1016/j.msard.2019.08.011
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101369Informations de copyright
Copyright © 2019. Published by Elsevier B.V.