Improvement of Redox State and Functions of Immune Cells as Well as of Behavioral Response in Aged Mice After Two-Week Supplementation of Fermented Milk with Probiotics.
Aging
/ drug effects
Animals
Behavior, Animal
/ drug effects
Female
Humans
Immune System
/ drug effects
Lacticaseibacillus casei
/ physiology
Lactobacillus delbrueckii
/ physiology
Mice
Mice, Inbred ICR
Oxidation-Reduction
/ drug effects
Probiotics
/ administration & dosage
Streptococcus thermophilus
/ physiology
Yogurt
/ analysis
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
04
06
2019
accepted:
13
08
2019
pubmed:
26
8
2019
medline:
31
12
2019
entrez:
26
8
2019
Statut:
ppublish
Résumé
The homeostatic systems, such as the nervous and immune systems, show deterioration in aging as a consequence of the age-related oxidative-inflammatory stress establishment. The supplementation with fermented milk containing probiotic bacteria could be a good nutritional strategy to improve homeostatic system functions in aged individuals through the modulation of their redox state. The aim of the present study was to evaluate the effect of 2-week supplementation with a commercial fermented milk containing yogurt species (Lactobacillus delbrueckii subsp. bulgaricus and Streptococcus thermophilus), and the probiotic Lactobacillus casei DN-114001 on behavior, redox state, and immune cell functions of aged mice as well as on their life span. Aged female ICR-CD1 mice were supplemented with fermented milk containing these probiotics for 2 weeks. After this period, a variety of behavioral tests were performed and several parameters of redox state and function of peritoneal leukocytes were analyzed. The results showed that the 2-week supplementation of fermented milk containing probiotics improved behavior (such as muscular vigor, exploratory activity, and anxiety-like behavior) as well as the redox state and functions of peritoneal immune cells in aged mice. In conclusion, the present study shows that the supplementation with fermented milk containing probiotics for a short period of time could be a good nutritional strategy to promote healthy aging.
Identifiants
pubmed: 31446476
doi: 10.1007/s00284-019-01759-9
pii: 10.1007/s00284-019-01759-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1278-1289Subventions
Organisme : Research Group of Madrid Complutense University
ID : 910379ENEROINN
Organisme : Instituto de Salud Carlos III
ID : PI15/01787
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