Dextromethorphan and memantine after ketamine analgesia: a randomized control trial.
N-methyl-D-aspartate antagonists
cognitive-affective status
drug relay
health-related quality of life
peripheral neuropathic pain
Journal
Drug design, development and therapy
ISSN: 1177-8881
Titre abrégé: Drug Des Devel Ther
Pays: New Zealand
ID NLM: 101475745
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
03
2019
accepted:
05
06
2019
entrez:
27
8
2019
pubmed:
27
8
2019
medline:
9
4
2020
Statut:
epublish
Résumé
Intravenous ketamine is often prescribed in severe neuropathic pain. Oral A multicenter randomized controlled clinical trial included 60 patients after ketamine infusion for refractory neuropathic pain. Dextromethorphan (90 mg/day), memantine (20 mg/day) or placebo was given for 12 weeks (n=20 each) after ketamine infusion. The primary endpoint was pain intensity at one month. Secondary endpoints included pain, sleep, anxiety, depression, cognitive function and quality of life evaluations up to 12 weeks. At 1 month, dextromethorphan maintained ketamine pain relief (Numeric Pain Scale: 4.01±1.87 to 4.05±2.61, Oral dextromethorphan given after ketamine infusion extends pain relief during one month and could help patients to better cope with pain. Future studies should include larger populations stratified on pharmacogenetics screening. Optimization of an oral drug that could extend ketamine antihyperalgesia, with fewer hospital admissions, remains a prime challenge in refractory neuropathic pain.
Identifiants
pubmed: 31447547
doi: 10.2147/DDDT.S207350
pii: 207350
pmc: PMC6683947
doi:
Substances chimiques
Ketamine
690G0D6V8H
Dextromethorphan
7355X3ROTS
Memantine
W8O17SJF3T
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
2677-2688Déclaration de conflit d'intérêts
The authors report no conflicts of interest in this work.
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