Vaccine-Induced Carbohydrate-Specific Memory B Cells Reactivate During Rodent Malaria Infection.
B cell immunity
glycosylphosphatidylinositol (GPI)
malaria
memory failure
vaccines
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
18
01
2019
accepted:
22
07
2019
entrez:
27
8
2019
pubmed:
27
8
2019
medline:
21
10
2020
Statut:
epublish
Résumé
A long-standing challenge in malaria is the limited understanding of B cell immunity, previously hampered by lack of tools to phenotype rare antigen-specific cells. Our aim was to develop a method for identifying carbohydrate-specific B cells within lymphocyte populations and to determine whether a candidate vaccine generated functional memory B cells (MBCs) that reactivated upon challenge with
Identifiants
pubmed: 31447848
doi: 10.3389/fimmu.2019.01840
pmc: PMC6696980
doi:
Substances chimiques
Glycosylphosphatidylinositols
0
Immunoglobulin G
0
Malaria Vaccines
0
Hemocyanins
9013-72-3
keyhole-limpet hemocyanin
FV4Y0JO2CX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1840Subventions
Organisme : Medical Research Council
Pays : United Kingdom
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