The Mononuclear Phagocytic System. Generation of Diversity.
macrophage
macrophage heterogeneity
macrophage receptors
monocyte
mononuclear phagocyte
plasticity
tissue-specific function
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
05
2019
accepted:
26
07
2019
entrez:
27
8
2019
pubmed:
27
8
2019
medline:
21
10
2020
Statut:
epublish
Résumé
We are living through an unprecedented accumulation of data on gene expression by macrophages, reflecting their origin, distribution, and localization within all organs of the body. While the extensive heterogeneity of the cells of the mononuclear phagocyte system is evident, the functional significance of their diversity remains incomplete, nor is the mechanism of diversification understood. In this essay we review some of the implications of what we know, and draw attention to issues to be clarified in further research, taking advantage of the powerful genetic, cellular, and molecular tools now available. Our thesis is that macrophage specialization and functions go far beyond immunobiology, while remaining an essential contributor to innate as well as adaptive immunity.
Identifiants
pubmed: 31447860
doi: 10.3389/fimmu.2019.01893
pmc: PMC6696592
doi:
Substances chimiques
Antigens
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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