T Cells Control Chemokine Secretion by Keratinocytes.


Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 31 05 2019
accepted: 29 07 2019
entrez: 27 8 2019
pubmed: 27 8 2019
medline: 21 10 2020
Statut: epublish

Résumé

The massive infiltration of lymphocytes into the skin is a hallmark of numerous human skin disorders. By co-culturing murine keratinocytes with splenic T cells we demonstrate here that T cells affect and control the synthesis and secretion of chemokines by keratinocytes. While pre-activated CD8

Identifiants

pubmed: 31447864
doi: 10.3389/fimmu.2019.01917
pmc: PMC6696622
doi:

Substances chimiques

Chemokines 0
Pdcd1 protein, mouse 0
Programmed Cell Death 1 Receptor 0
CD40 Ligand 147205-72-9

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1917

Références

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Auteurs

Tabea Rauschenberger (T)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.

Viola Schmitt (V)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.

Muhammad Azeem (M)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.

Stefan Klein-Hessling (S)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Comprehensive Cancer Center Mainfranken, Würzburg, Germany.

Krisna Murti (K)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.

Franziska Grän (F)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Matthias Goebeler (M)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Andreas Kerstan (A)

Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Würzburg, Germany.

Matthias Klein (M)

Institute for Immunology, University Medical Center, University of Mainz, Mainz, Germany.
Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, Mainz, Germany.

Tobias Bopp (T)

Institute for Immunology, University Medical Center, University of Mainz, Mainz, Germany.
Research Center for Immunotherapy (FZI), University Medical Center, University of Mainz, Mainz, Germany.
Department of Immunology, University Cancer Center Mainz, University Medical Center, University of Mainz, Mainz, Germany.

Edgar Serfling (E)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Comprehensive Cancer Center Mainfranken, Würzburg, Germany.

Khalid Muhammad (K)

Department of Molecular Pathology, Institute of Pathology, University of Würzburg, Würzburg, Germany.
Comprehensive Cancer Center Mainfranken, Würzburg, Germany.

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Classifications MeSH