Human Herpesvirus 6B and Lower Respiratory Tract Disease After Hematopoietic Cell Transplantation.
Adult
Antiviral Agents
/ therapeutic use
Bronchoalveolar Lavage Fluid
/ virology
Cohort Studies
DNA, Viral
/ analysis
Female
Hematopoietic Stem Cell Transplantation
/ adverse effects
Herpesvirus 6, Human
/ genetics
Humans
Male
Middle Aged
RNA, Viral
/ analysis
Respiratory Tract Infections
/ drug therapy
Retrospective Studies
Roseolovirus Infections
/ drug therapy
Viral Load
Young Adult
Journal
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
ISSN: 1527-7755
Titre abrégé: J Clin Oncol
Pays: United States
ID NLM: 8309333
Informations de publication
Date de publication:
10 10 2019
10 10 2019
Historique:
pubmed:
27
8
2019
medline:
18
6
2020
entrez:
27
8
2019
Statut:
ppublish
Résumé
Human herpesvirus 6B (HHV-6B) DNA is frequently detected in bronchoalveolar lavage fluid (BALF) from immunocompromised subjects with lower respiratory tract disease (LRTD). Whether HHV-6B is a pulmonary pathogen is unclear. We tested BALF for HHV-6B DNA using polymerase chain reaction in allogeneic hematopoietic cell transplantation (HCT) recipients who underwent a BAL for evaluation of LRTD from 1992 to 2015. We used multivariable proportional hazards models to evaluate the association of HHV-6B We detected HHV-6B These data provide evidence that HHV-6B detection in BALF is associated with higher mortality in allogeneic hematopoietic cell transplantation recipients with LRTD. Definitive evidence of causation will require a randomized prevention or treatment trial.
Identifiants
pubmed: 31449472
doi: 10.1200/JCO.19.00908
pmc: PMC7351330
doi:
Substances chimiques
Antiviral Agents
0
DNA, Viral
0
RNA, Viral
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2670-2681Subventions
Organisme : NIAID NIH HHS
ID : K23 AI119133
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL143050
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL093294
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA078902
Pays : United States
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