Serum active 1,25(OH)
Adiposity
Aged
Cardiovascular Diseases
/ blood
Coronary Angiography
Coronary Vessels
/ physiopathology
Female
Fluorodeoxyglucose F18
Humans
Immunoassay
Intra-Abdominal Fat
Male
Middle Aged
Plaque, Atherosclerotic
/ blood
Positron Emission Tomography Computed Tomography
Prospective Studies
Psoriasis
/ blood
Risk
Vitamin D
/ analogs & derivatives
Coronary artery disease
Imaging
Inflammation
Psoriasis
Vitamin D
Journal
Atherosclerosis
ISSN: 1879-1484
Titre abrégé: Atherosclerosis
Pays: Ireland
ID NLM: 0242543
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
24
04
2019
revised:
09
07
2019
accepted:
16
08
2019
pubmed:
27
8
2019
medline:
15
8
2020
entrez:
27
8
2019
Statut:
ppublish
Résumé
Vitamin D exists as an inactive 25-hydroxyvitamin D (25(OH)D) in the bloodstream, which is converted to active 1,25-dihydroxyvitaminD (1,25(OH) Consecutive psoriasis patients (N = 122) at baseline underwent FDG PET/CT and CCTA scans to measure visceral adipose volume, aortic vascular uptake of FDG, and coronary plaque burden respectively. Blood levels of both 1,25(OH) The psoriasis cohort was middle-aged (mean ± SD: 49.6 ± 13.0), predominantly male (n = 71, 58%), in majority Caucasians (n = 98, 80%), and had moderate-to-severe skin disease [psoriasis area severity index score, PASI score, med. 5.5 (3.2-10.7)], with almost one-fourth of the cohort on biologic psoriasis therapy for skin disease management (n = 32, 27%) at baseline. Interestingly, serum levels of 1,25(OH) In conclusion, we demonstrate that low 1,25(OH)
Sections du résumé
BACKGROUND AND AIMS
Vitamin D exists as an inactive 25-hydroxyvitamin D (25(OH)D) in the bloodstream, which is converted to active 1,25-dihydroxyvitaminD (1,25(OH)
METHODS
Consecutive psoriasis patients (N = 122) at baseline underwent FDG PET/CT and CCTA scans to measure visceral adipose volume, aortic vascular uptake of FDG, and coronary plaque burden respectively. Blood levels of both 1,25(OH)
RESULTS
The psoriasis cohort was middle-aged (mean ± SD: 49.6 ± 13.0), predominantly male (n = 71, 58%), in majority Caucasians (n = 98, 80%), and had moderate-to-severe skin disease [psoriasis area severity index score, PASI score, med.
(IQR)
5.5 (3.2-10.7)], with almost one-fourth of the cohort on biologic psoriasis therapy for skin disease management (n = 32, 27%) at baseline. Interestingly, serum levels of 1,25(OH)
CONCLUSIONS
In conclusion, we demonstrate that low 1,25(OH)
Identifiants
pubmed: 31450013
pii: S0021-9150(19)31440-6
doi: 10.1016/j.atherosclerosis.2019.08.006
pmc: PMC7428835
mid: NIHMS1538204
pii:
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Observational Study
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-50Subventions
Organisme : Intramural NIH HHS
ID : ZIA HL006193-05
Pays : United States
Organisme : Intramural NIH HHS
ID : ZIA HL006235-01
Pays : United States
Informations de copyright
Published by Elsevier B.V.
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