Prenatal and Postnatal Hair Steroid Levels Predict Post-Partum Depression 12 Weeks after Delivery.
DHEA
cortisol
cortisone
post-partum depression
pre- and postnatal hair steroids
progesterone
testosterone
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
23 08 2019
23 08 2019
Historique:
received:
01
08
2019
revised:
08
08
2019
accepted:
16
08
2019
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
28
8
2019
Statut:
epublish
Résumé
Within three to six months after delivery, 13%-19% of women suffer from post-partum depression (PPD), understood as a dysfunctional adaptation to the postpartum condition and motherhood. In the present cross-sectional study, we compared the hair steroid levels of women 12 weeks before and after delivery and with or without PPD. The present study was a cross-sectional study conducted twelve weeks after delivery. At that time, 48 women (mean age: 25.9 years) with PPD and 50 healthy controls (mean age: 25.2 years) completed questionnaires on depressive symptoms. Further, at the same time point, 6 cm lengths of hair strands were taken, providing samples of hair steroids 12 weeks before and 12 weeks after delivery in order to analyze hair steroids (cortisol, cortisone, progesterone, testosterone, and dehydroepiandrosterone (DHEA)). Compared to those of women without PPD, hair steroid levels (cortisol, cortisone, progesterone) were significantly lower in women with PPD both before and after delivery. Lower prenatal cortisone and progesterone levels predicted higher depression scores 12 weeks after delivery. Lower prenatal levels of cortisol and progesterone and higher levels of DHEA, and postnatal lower levels of cortisol, cortisone, and progesterone, along with higher levels of DHEA predicted PPD-status with an accuracy of 98%. PPD is associated with blunted hair cortisol, cortisone, and progesterone secretions both pre- and postpartum. Such blunted steroid levels appear to reflect a stress responsivity that is less adaptive to acute and transient stressors. It follows that prenatally assessed low hair cortisol and progesterone levels, along with high DHEA levels, are reliable biomarkers of post-partum depression 12 weeks after delivery.
Sections du résumé
BACKGROUND
Within three to six months after delivery, 13%-19% of women suffer from post-partum depression (PPD), understood as a dysfunctional adaptation to the postpartum condition and motherhood. In the present cross-sectional study, we compared the hair steroid levels of women 12 weeks before and after delivery and with or without PPD.
METHOD
The present study was a cross-sectional study conducted twelve weeks after delivery. At that time, 48 women (mean age: 25.9 years) with PPD and 50 healthy controls (mean age: 25.2 years) completed questionnaires on depressive symptoms. Further, at the same time point, 6 cm lengths of hair strands were taken, providing samples of hair steroids 12 weeks before and 12 weeks after delivery in order to analyze hair steroids (cortisol, cortisone, progesterone, testosterone, and dehydroepiandrosterone (DHEA)).
RESULTS
Compared to those of women without PPD, hair steroid levels (cortisol, cortisone, progesterone) were significantly lower in women with PPD both before and after delivery. Lower prenatal cortisone and progesterone levels predicted higher depression scores 12 weeks after delivery. Lower prenatal levels of cortisol and progesterone and higher levels of DHEA, and postnatal lower levels of cortisol, cortisone, and progesterone, along with higher levels of DHEA predicted PPD-status with an accuracy of 98%.
CONCLUSIONS
PPD is associated with blunted hair cortisol, cortisone, and progesterone secretions both pre- and postpartum. Such blunted steroid levels appear to reflect a stress responsivity that is less adaptive to acute and transient stressors. It follows that prenatally assessed low hair cortisol and progesterone levels, along with high DHEA levels, are reliable biomarkers of post-partum depression 12 weeks after delivery.
Identifiants
pubmed: 31450789
pii: jcm8091290
doi: 10.3390/jcm8091290
pmc: PMC6780455
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Jun 1;928:1-8
pubmed: 23584040
Arch Gen Psychiatry. 1961 Jun;4:561-71
pubmed: 13688369
Arch Womens Ment Health. 2016 Apr;19(2):317-28
pubmed: 26275372
Horm Behav. 2016 Jan;77:153-66
pubmed: 26319224
Stress. 2012 Nov;15(6):578-88
pubmed: 22356099
J Clin Psychiatry. 1998;59 Suppl 20:22-33;quiz 34-57
pubmed: 9881538
Psychoneuroendocrinology. 2015 Feb;52:289-96
pubmed: 25553388
Neuropsychobiology. 2017;75(1):12-20
pubmed: 28750407
Biol Psychiatry. 2010 Jun 1;67(11):1026-32
pubmed: 20188350
PLoS One. 2017 Aug 28;12(8):e0182817
pubmed: 28846691
Psychoneuroendocrinology. 2011 Sep;36(8):1193-200
pubmed: 21411229
J Affect Disord. 2016 Mar 15;193:391-404
pubmed: 26802316
Best Pract Res Clin Obstet Gynaecol. 2014 Jan;28(1):3-12
pubmed: 24140480
Eur J Endocrinol. 2015 Oct;173(4):M1-10
pubmed: 25924811
Physiol Behav. 2011 Aug 3;104(2):348-53
pubmed: 21397617
Depress Anxiety. 2005;21(4):185-92
pubmed: 16075452
Neuropeptides. 2013 Dec;47(6):363-70
pubmed: 24210135
Harv Rev Psychiatry. 2014 Jan-Feb;22(1):1-22
pubmed: 24394219
Neuropsychiatr Dis Treat. 2016 Jun 09;12:1333-9
pubmed: 27354803
Biol Psychiatry. 2013 Nov 1;74(9):e15-7
pubmed: 23726317
Annu Rev Clin Psychol. 2013;9:379-407
pubmed: 23394227
Annu Rev Psychol. 2010;61:81-109, C1-11
pubmed: 19575614
Infant Behav Dev. 2006 Apr;29(2):262-7
pubmed: 17138281
Arch Womens Ment Health. 2006 Nov;9(6):309-15
pubmed: 17013761
J Affect Disord. 2004 May;80(1):65-73
pubmed: 15094259
Lancet. 2016 Feb 6;387(10018):505
pubmed: 26867429
Int J Methods Psychiatr Res. 2011 Dec;20(4):224-34
pubmed: 22113965
Clin Invest Med. 2007;30(2):E103-7
pubmed: 17716540
Int J Neurosci. 2008 Jan;118(1):95-103
pubmed: 18041608
Psychol Bull. 2007 Jan;133(1):25-45
pubmed: 17201569
Clin Biochem. 2019 Jan;63:1-9
pubmed: 30261181
CNS Spectr. 2015 Feb;20(1):48-59
pubmed: 25263255
Psychol Med. 2018 May;48(7):1190-1200
pubmed: 28950923
Biol Psychiatry. 2013 Nov 1;74(9):639-46
pubmed: 23623187
Stress. 2013 Nov;16(6):593-9
pubmed: 23855828
Brain Behav Immun. 2012 Oct;26(7):1019-29
pubmed: 22366690
PLoS One. 2016 Sep 01;11(9):e0161804
pubmed: 27584584
BMC Pregnancy Childbirth. 2015 May 03;15:108
pubmed: 25935726
Paediatr Perinat Epidemiol. 2016 Mar;30(2):97-104
pubmed: 26525484
J Clin Psychiatry. 2001;62 Suppl 17:41-6
pubmed: 11495096
BMC Pregnancy Childbirth. 2016 May 31;16(1):124
pubmed: 27245670
Neuropsychobiology. 2013;68(2):100-9
pubmed: 23881183
Neuroendocrinology. 2013;98(2):106-15
pubmed: 23969897
Endocrinology. 2011 Dec;152(12):4496-503
pubmed: 21971152
Br J Psychiatry. 1987 Jun;150:782-6
pubmed: 3651732
J Clin Endocrinol Metab. 2011 May;96(5):1533-40
pubmed: 21367926
Eur J Obstet Gynecol Reprod Biol. 2016 Nov;206:99-104
pubmed: 27664907
Behav Res Methods. 2007 May;39(2):175-91
pubmed: 17695343
Arch Womens Ment Health. 2018 Apr;21(2):149-161
pubmed: 29022126
Annu Rev Clin Psychol. 2015;11:99-137
pubmed: 25822344
Infant Behav Dev. 2010 Feb;33(1):23-9
pubmed: 19945170
Neurol Sci. 2011 May;32 Suppl 1:S31-5
pubmed: 21533709
Ann Epidemiol. 2013 Dec;23(12):797-811.e2
pubmed: 24184029
Stress. 2012 May;15(3):348-53
pubmed: 22043813
Ann N Y Acad Sci. 2003 Nov;997:136-49
pubmed: 14644820
J Affect Disord. 2016 Mar 15;193:249-56
pubmed: 26773916
Syst Rev. 2019 Jan 7;8(1):7
pubmed: 30616687
Psychoneuroendocrinology. 2018 Mar;89:138-146
pubmed: 29358120
J Obstet Gynaecol Res. 2011 Aug;37(8):1004-9
pubmed: 21463431
Psychoneuroendocrinology. 2019 Jun;104:191-194
pubmed: 30856425
Stress. 2019 Jan;22(1):60-69
pubmed: 30585520
Psychoneuroendocrinology. 2009 Jan;34(1):32-7
pubmed: 18947933
Soc Sci Med. 2017 Feb;175:228-234
pubmed: 28109728
Psychoneuroendocrinology. 2017 Mar;77:261-274
pubmed: 28135674