Immune-Mediated Inflammation in Vulnerable Atherosclerotic Plaques.
atherosclerosis
cardiovascular disease
immune activation
inflammation
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
23 Aug 2019
23 Aug 2019
Historique:
received:
02
07
2019
revised:
21
08
2019
accepted:
22
08
2019
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
22
1
2020
Statut:
epublish
Résumé
Atherosclerosis is a chronic long-lasting vascular disease leading to myocardial infarction and stroke. Vulnerable atherosclerotic (AS) plaques are responsible for these life-threatening clinical endpoints. To more successfully work against atherosclerosis, improvements in early diagnosis and treatment of AS plaque lesions are required. Vulnerable AS plaques are frequently undetectable by conventional imaging because they are non-stenotic. Although blood biomarkers like lipids, C-reactive protein, interleukin-6, troponins, and natriuretic peptides are in pathological ranges, these markers are insufficient in detecting the critical perpetuation of AS anteceding endpoints. Thus, chances to treat the patient in a preventive way are wasted. It is now time to solve this dilemma because clear results indicate a benefit of anti-inflammatory therapy per se without modification of blood lipids (CANTOS Trial, NCT01327846). This fact identifies modulation of immune-mediated inflammation as a new promising point of action for the eradication of fatal atherosclerotic endpoints.
Identifiants
pubmed: 31450823
pii: molecules24173072
doi: 10.3390/molecules24173072
pmc: PMC6749340
pii:
doi:
Substances chimiques
Biomarkers
0
Matrix Metalloproteinases
EC 3.4.24.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
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