Acid-sensing ion channels (ASICs) influence excitability of stellate neurons in the mouse cochlear nucleus.
ASIC
Acid-sensing ion channels
Auditory pathway
Cochlear nucleus
Patch-clamp technique
Journal
Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology
ISSN: 1432-1351
Titre abrégé: J Comp Physiol A Neuroethol Sens Neural Behav Physiol
Pays: Germany
ID NLM: 101141792
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
20
02
2019
accepted:
13
08
2019
revised:
08
08
2019
pubmed:
28
8
2019
medline:
15
9
2020
entrez:
28
8
2019
Statut:
ppublish
Résumé
Acid-sensing ion channels (ASICs) are voltage-independent and proton-gated channels. In this study, we aimed to test the hypothesis whether ASICs might be involved in modifying the excitability of stellate cells in the cochlear nucleus (CN). We determined gene expressions of ASIC1, ASIC2 and ASIC3 in the CN of BALB/mice. ASIC currents in stellate cells were characterized by using whole-cell patch-clamp technique. In the voltage-clamp experiments, inward currents were recorded upon application of 2-[N-Morpholino ethanesulfonic acid]-normal artificial cerebrospinal fluid (MES-aCSF), whose pH 50 was 5.84. Amiloride inhibited the acid-induced currents in a dose-dependent manner. Inhibition of the ASIC currents by extracellular Ca
Identifiants
pubmed: 31451914
doi: 10.1007/s00359-019-01365-x
pii: 10.1007/s00359-019-01365-x
doi:
Substances chimiques
Acid Sensing Ion Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
769-781Références
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