Effect of placental growth factor in models of experimental pre-eclampsia and trophoblast invasion.
Animals
Cells, Cultured
Coculture Techniques
/ methods
Endothelial Cells
/ metabolism
Female
Humans
Mice
Mice, Inbred C57BL
Placenta
/ metabolism
Placenta Growth Factor
/ metabolism
Pre-Eclampsia
/ metabolism
Pregnancy
Proteinuria
/ metabolism
Trophoblasts
/ metabolism
Tumor Necrosis Factor-alpha
/ metabolism
Uterus
/ metabolism
placental MRI
placental growth factor
pre-eclampsia
trophoblast invasion
Journal
Clinical and experimental pharmacology & physiology
ISSN: 1440-1681
Titre abrégé: Clin Exp Pharmacol Physiol
Pays: Australia
ID NLM: 0425076
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
14
05
2019
accepted:
22
08
2019
pubmed:
28
8
2019
medline:
4
5
2021
entrez:
28
8
2019
Statut:
ppublish
Résumé
Placental growth factor (PlGF) is decreased in early gestation of pregnant women who subsequently develop pre-eclampsia. In this study, pre-emptive treatment with PlGF to prevent pre-eclampsia was evaluated in an in vivo rodent model of experimental pre-eclampsia (EPE) induced by TNF-α and in an in vitro model of human first-trimester trophoblast invasion. Pregnant C57/BL6 mice were treated with recombinant mouse placental growth factor-2 (rmPlGF-2) 100 μg/kg/day IP from gestational day (gd) 10. Animals had EPE induced by continuous TNF-α infusion on gd 13 and were subject to either continuous blood pressure monitoring by radiotelemetry throughout pregnancy or live placenta T
Identifiants
pubmed: 31452230
doi: 10.1111/1440-1681.13169
doi:
Substances chimiques
Pgf protein, mouse
0
Tumor Necrosis Factor-alpha
0
Placenta Growth Factor
144589-93-5
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
49-59Informations de copyright
© 2019 John Wiley & Sons Australia, Ltd.
Références
Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, et al. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350(7):672-683.
Powers RW, Jeyabalan A, Clifton RG, Van Dorsten P, Hauth JC, Klebanoff MA, et al. Soluble fms-Like tyrosine kinase 1 (sFlt1), endoglin and placental growth factor (PlGF) in preeclampsia among high risk pregnancies. PLoS ONE. 2010;5(10):e13263.
Poon LC, Zaragoza E, Akolekar R, Anagnostopoulos E, Nicolaides KH. Maternal serum placental growth factor (PlGF) in small for gestational age pregnancy at 11(+0) to 13(+6) weeks of gestation. Prenat Diagn. 2008;28(12):1110-1115.
Sunderland N, Hennessy A, Makris A. Animal models of pre-eclampsia. Am J Reprod Immunol. 2011;65(6):533-541.
Granger JPBW, Alexander BT, Cockrell KL, Whitworth NS. Long-term elevation of plasma TNF-alpha increases arterial pressure and reduces kidney function in pregnant rats. Hypertension. 1999;34(2):337.
Murphy SR, LaMarca BB, Parrish M, Cockrell K, Granger JP. Control of soluble fms-like tyrosine-1 (sFlt-1) production response to placental ischemia/hypoxia: role of tumor necrosis factor-alpha. Am J Physiol Regul Integr Comp Physiol. 2013;304(2):R130-R135.
Bobek G, Surmon L, Mirabito KM, Makris A, Hennessy A. Placental regulation of inflammation and hypoxia after TNF-alpha infusion in mice. Am J Reprod Immunol. 2015;74(5):407-418.
Bobek G, Stait-Gardner T, Surmon L, Makris A, Lind JM, Price WS, et al. Magnetic resonance imaging detects placental hypoxia and acidosis in mouse models of perturbed pregnancies. PLoS ONE. 2013;8(3):e59971.
Spradley FT, Tan AY, Joo WS, Daniels G, Kussie P, Karumanchi SA, et al. Placental growth factor administration abolishes placental ischemia-induced hypertension. Hypertension. 2016;67(4):740-747.
Zhu M, Ren Z, Possomato-Vieira JS, Khalil RA. Restoring placental growth factor-soluble fms-like tyrosine kinase-1 balance reverses vascular hyper-reactivity and hypertension in pregnancy. Am J Physiol Regul Integr Comp Physiol. 2016;311(3):R505-R521.
Makris A, Yeung KR, Lim SM, Sunderland N, Heffernan S, Thompson JF, et al. Placental growth factor reduces blood pressure in a uteroplacental ischemia model of preeclampsia in nonhuman primates. Hypertension. 2016;67(6):1263-1272.
Suzuki H, Ohkuchi A, Matsubara S, Takei Y, Murakami M, Shibuya M, et al. Effect of recombinant placental growth factor 2 on hypertension induced by full-length mouse soluble fms-like tyrosine kinase 1 adenoviral vector in pregnant mice. Hypertension. 2009;54(5):1129-1135.
Sunderland NS, Thomson SE, Heffernan SJ, Lim S, Thompson J, Ogle R, et al. Tumor necrosis factor alpha induces a model of preeclampsia in pregnant baboons (Papio hamadryas). Cytokine. 2011;56(2):192-199.
Mu J, Slevin JC, Qu D, McCormick S, Adamson SL. In vivo quantification of embryonic and placental growth during gestation in mice using micro-ultrasound. Reprod Biol Endocrinol. 2008;6:34.
Kang MC, Park SJ, Kim HJ, Lee J, Yu DH, Bae KB, et al. Gestational loss and growth restriction by angiogenic defects in placental growth factor transgenic mice. Arterioscler Thromb Vasc Biol. 2014;34(10):2276-2282.
Koga K, Mor G. Toll-like receptors at the maternal-fetal interface in normal pregnancy and pregnancy disorders. Am J Reprod Immunol. 2010;63(6):587-600.
Chatterjee P, Chiasson VL, Kopriva SE, Young KJ, Chatterjee V, Jones KA, et al. Interleukin 10 deficiency exacerbates toll-like receptor 3-induced preeclampsia-like symptoms in mice. Hypertension. 2011;58(3):489-496.
Chatterjee P, Weaver LE, Doersch KM, Kopriva SE, Chiasson VL, Allen SJ, et al. Placental Toll-like receptor 3 and Toll-like receptor 7/8 activation contributes to preeclampsia in humans and mice. PLoS ONE. 2012;7(7):e41884.
Helske S, Vuorela P, Carpen O, Hornig C, Weich H, Halmesmaki E. Expression of vascular endothelial growth factor receptors 1, 2 and 3 in placentas from normal and complicated pregnancies. Mol Hum Reprod. 2001;7(2):205-210.
De Falco S. The discovery of placenta growth factor and its biological activity. Exp Mol Med. 2012;44(1):1-9.
Aasa KL, Zavan B, Luna RL, Wong PG, Ventura NM, Tse MY, et al. Placental growth factor influences maternal cardiovascular adaptation to pregnancy in mice. Biol Reprod. 2015;92(2):44.
Parchem JG, Kanasaki K, Kanasaki M, Sugimoto H, Xie L, Hamano Y, et al. Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice. J Clin Invest. 2018;128(11):5008-5017.
National Health and Medical Research Council. Guidelines to Promote the Wellbeing of Animals Used for Scientific Purposes. Canberra, Australia: Australian Government; 2008.
Burke SD. Radiotelemetry in mouse pregnancy. In: Croy A, Yamada AT, DeMayo FJ, Adamson SL, eds. The Guide To Investigation Of Mouse Pregnancy, 1st edn. Cambridge, MA: Academic Press; 2014:649-659.
Surmon L, Bobek G, Chiu CL, Young S, Makris A, Lind JM, et al. The expression of placental soluble fms-like tyrosine kinase 1 in mouse placenta varies significantly across different litters from normal pregnant mice. Hypertens Pregnancy. 2014;33(3):371-374.
Chiu CL, Morgan CT, Lupton SJ, Lind JM. Parent of origin influences the cardiac expression of vascular endothelial growth factor (Vegfa). BMC Med Genet. 2013;14:43.
Huckle WR, Roche RI. Post-transcriptional control of expression of sFlt-1, an endogenous inhibitor of vascular endothelial growth factor. J Cell Biochem. 2004;93(1):120-132.
Xu B, Charlton F, Makris A, Hennessy A. Antihypertensive drugs methyldopa, labetalol, hydralazine, and clonidine improve trophoblast interaction with endothelial cellular networks in vitro. J Hypertens. 2014;32(5):1075-1083; discussion 83
Xu B, Shanmugalingam R, Chau K, Pears S, Hennessy A, Makris A. The effect of acetyl salicylic acid (Aspirin) on trophoblast-endothelial interaction in vitro. J Reprod Immunol. 2017;124:54-61.
Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, et al. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene. 2005;24:2647.
Charlton F, Bobek G, Stait-Gardner T, Price WS, Mirabito Colafella KM, Xu B, et al. The protective effect of apolipoprotein in models of trophoblast invasion and preeclampsia. Am J Physiol Regul Integr Comp Physiol. 2017;312(1):R40-r8.
Xu B, Nakhla S, Makris A, Hennessy A. TNF-alpha inhibits trophoblast integration into endothelial cellular networks. Placenta. 2011;32(3):241-246.