Normal range for MR elastography measured liver stiffness in children without liver disease.
hepatic shear stiffness
magnetic resonance imaging
pediatric radiology
quantitative imaging biomarkers
Journal
Journal of magnetic resonance imaging : JMRI
ISSN: 1522-2586
Titre abrégé: J Magn Reson Imaging
Pays: United States
ID NLM: 9105850
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
17
05
2019
accepted:
05
08
2019
pubmed:
28
8
2019
medline:
15
5
2021
entrez:
28
8
2019
Statut:
ppublish
Résumé
Magnetic resonance elastography (MRE) can determine the presence and stage of liver fibrosis. Data on normative MRE values, while reported in adults, are limited in children. To determine the distribution of MRE-measured liver stiffness in children without liver disease. Prospective, observational. Eighty-one healthy children (mean 12.6 ± 2.6 years, range 8-17 years). 3.0T Signa HDxt, General Electric MR Scanner; 2D GRE MRE sequence. History, examination, laboratory evaluation, and (MR) exams (proton density fat fraction, PDFF, and MRE) were performed. MR elastograms were analyzed manually at two reading centers and compared with each other for agreement and with published values in healthy adults and thresholds for fibrosis in adult and pediatric patients. Descriptive statistics, Bland-Altman analysis, t-test to compare hepatic stiffness values with reference standards. Stiffness values obtained at both reading centers were similar, without significant bias (P = 0.362) and with excellent correlation (intraclass correlation coefficient [ICC] = 0.782). Mean hepatic stiffness value for the study population was 2.45 ± 0.35 kPa (95 Mean liver stiffness measured with MRE in this cohort was significantly higher than that reported in healthy adults. Despite rigorous screening, some healthy children had stiffness measurements suggestive of liver fibrosis using current published thresholds. Although MRE has the potential to provide noninvasive assessment in patients with suspected hepatic disease, further refinement of this technology will help advance its use as a diagnostic tool for evidence of fibrosis in pediatric populations. 1 Technical Efficacy: 5 J. Magn. Reson. Imaging 2020;51:919-927.
Sections du résumé
BACKGROUND
Magnetic resonance elastography (MRE) can determine the presence and stage of liver fibrosis. Data on normative MRE values, while reported in adults, are limited in children.
PURPOSE
To determine the distribution of MRE-measured liver stiffness in children without liver disease.
STUDY TYPE
Prospective, observational.
POPULATION
Eighty-one healthy children (mean 12.6 ± 2.6 years, range 8-17 years).
FIELD STRENGTH/SEQUENCE
3.0T Signa HDxt, General Electric MR Scanner; 2D GRE MRE sequence.
ASSESSMENT
History, examination, laboratory evaluation, and (MR) exams (proton density fat fraction, PDFF, and MRE) were performed. MR elastograms were analyzed manually at two reading centers and compared with each other for agreement and with published values in healthy adults and thresholds for fibrosis in adult and pediatric patients.
STATISTICAL TESTS
Descriptive statistics, Bland-Altman analysis, t-test to compare hepatic stiffness values with reference standards.
RESULTS
Stiffness values obtained at both reading centers were similar, without significant bias (P = 0.362) and with excellent correlation (intraclass correlation coefficient [ICC] = 0.782). Mean hepatic stiffness value for the study population was 2.45 ± 0.35 kPa (95
DATA CONCLUSION
Mean liver stiffness measured with MRE in this cohort was significantly higher than that reported in healthy adults. Despite rigorous screening, some healthy children had stiffness measurements suggestive of liver fibrosis using current published thresholds. Although MRE has the potential to provide noninvasive assessment in patients with suspected hepatic disease, further refinement of this technology will help advance its use as a diagnostic tool for evidence of fibrosis in pediatric populations.
LEVEL OF EVIDENCE
1 Technical Efficacy: 5 J. Magn. Reson. Imaging 2020;51:919-927.
Identifiants
pubmed: 31452280
doi: 10.1002/jmri.26905
pmc: PMC7386297
mid: NIHMS1603556
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
919-927Subventions
Organisme : National Institutes of Health (NIH)
ID : EB017197
Pays : International
Organisme : NIBIB NIH HHS
ID : R37 EB001981
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001442
Pays : United States
Organisme : National Institutes of Health (NIH)
ID : ULTR000100
Pays : International
Organisme : National Institutes of Health (NIH)
ID : UL1TR001442
Pays : International
Organisme : NIDDK NIH HHS
ID : R56 DK090350
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB017197
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000100
Pays : United States
Organisme : National Institutes of Health (NIH)
ID : UL1TR000100
Pays : International
Organisme : National Institutes of Health (NIH)
ID : ULTR001442
Pays : International
Organisme : NIBIB NIH HHS
ID : R01 EB001981
Pays : United States
Organisme : National Institutes of Health (NIH)
ID : EB001981
Pays : International
Informations de copyright
© 2019 International Society for Magnetic Resonance in Medicine.
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