Performance comparison of chlorinated chiral stationary phases in supercritical fluid chromatography for separation of selected pyrrolidone derivatives.
Antibacterial compounds
Chirality
Enantiomers
Flow-rate
Particle size
Journal
Journal of pharmaceutical analysis
ISSN: 2214-0883
Titre abrégé: J Pharm Anal
Pays: China
ID NLM: 101579451
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
03
12
2018
revised:
23
01
2019
accepted:
04
03
2019
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
28
8
2019
Statut:
ppublish
Résumé
The effects of two chlorinated chiral stationary phases, namely, Lux Cellulose-2 and Lux i-Cellulose-5, flow-rate, percentage of co-solvent and chemical structures of the compounds on retention and resolution were studied within this article. In this work a backpressure of 150 bar, a temperature of 40 °C and 10% of methanol as co-solvent were chosen as operating conditions. The optimum flow-rate was 2 mL/min. The percentage of co-solvent was studied between 7.5% and 15%. We have observed that 15% of methanol gave the best results for most of the compounds. For all the derivatives, the Lux Cellulose-2 provided better resolutions going from 1.50 to 3.59 compared with Lux i-Cellulose-5.
Identifiants
pubmed: 31452962
doi: 10.1016/j.jpha.2019.03.002
pii: S2095-1779(18)30505-7
pmc: PMC6702407
doi:
Types de publication
Journal Article
Langues
eng
Pagination
248-253Références
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