Determination of iohexol by capillary blood microsampling and UHPLC-MS/MS.
HemaPEN
Iohexol
LC-MS/MS
Microsampling
VAMS
Journal
Journal of pharmaceutical analysis
ISSN: 2214-0883
Titre abrégé: J Pharm Anal
Pays: China
ID NLM: 101579451
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
24
03
2019
revised:
25
06
2019
accepted:
26
06
2019
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
28
8
2019
Statut:
ppublish
Résumé
One of the most important tools used to evaluate kidney function in the context of chronic kidney disease or other renal function related pathologies is the exploration of glomerular filtration rate (GFR). Iohexol is up to this moment a good candidate molecule for the GFR assessment since it exhibits minimum protein binding rates and minimum extra-renal clearance, being neither secreted nor reabsorbed at the tubular level. This study proposes and evaluates a new LC-MS/MS method for the iohexol determination from capillary blood, prelevated using volumetric absorbative microsampling (VAMS) systems. As an alternative to VAMS, a brand new HemaPEN
Identifiants
pubmed: 31452964
doi: 10.1016/j.jpha.2019.06.003
pii: S2095-1779(19)30224-2
pmc: PMC6702420
doi:
Types de publication
Journal Article
Langues
eng
Pagination
259-265Références
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