DNA Methylation Trajectories During Pregnancy.
Cohort
DNA methylation
Illumina EPIC and Infinium chip
pregnancy
Journal
Epigenetics insights
ISSN: 2516-8657
Titre abrégé: Epigenet Insights
Pays: United States
ID NLM: 101735398
Informations de publication
Date de publication:
2019
2019
Historique:
received:
28
06
2019
accepted:
10
07
2019
entrez:
28
8
2019
pubmed:
28
8
2019
medline:
28
8
2019
Statut:
epublish
Résumé
There is emerging evidence on DNA methylation (DNAm) variability over time; however, little is known about dynamics of DNAm patterns during pregnancy. We performed an epigenome-wide longitudinal DNAm study of a well-characterized sample of young women from the Swedish Born into Life study, with repeated blood sampling before, during and after pregnancy (n = 21), using the Illumina Infinium MethylationEPIC array. We conducted a replication in the Isle of Wight third-generation birth cohort (n = 27), using the Infinium HumanMethylation450k BeadChip. We identified 196 CpG sites displaying intra-individual longitudinal change in DNAm with a false discovery rate (FDR)
Identifiants
pubmed: 31453433
doi: 10.1177/2516865719867090
pii: 10.1177_2516865719867090
pmc: PMC6696836
doi:
Types de publication
Journal Article
Langues
eng
Pagination
2516865719867090Subventions
Organisme : NIAID NIH HHS
ID : R01 AI091905
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132321
Pays : United States
Déclaration de conflit d'intérêts
Declaration of conflicting interests:The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.
Références
Am J Pathol. 2001 Mar;158(3):955-66
pubmed: 11238043
Respir Res. 2001;2(1):20-6
pubmed: 11686861
Cell Growth Differ. 2002 Apr;13(4):195-203
pubmed: 11971819
Trends Cardiovasc Med. 2003 Nov;13(8):336-45
pubmed: 14596950
Eur J Cell Biol. 2005 Jun;84(5):555-66
pubmed: 16003909
Biostatistics. 2007 Jan;8(1):118-27
pubmed: 16632515
Clin Obstet Gynecol. 2007 Dec;50(4):938-48
pubmed: 17982337
Gynecol Oncol. 2008 Mar;108(3):520-6
pubmed: 18191186
Bioinformatics. 2008 Jun 15;24(12):1461-2
pubmed: 18441000
JAMA. 2008 Jun 25;299(24):2877-83
pubmed: 18577732
Epigenetics. 2010 Aug 16;5(6):516-26
pubmed: 20505345
Sci Transl Med. 2010 Sep 15;2(49):49ra67
pubmed: 20844285
Eur J Epidemiol. 2011 Jan;26(1):67-77
pubmed: 21104112
BMC Bioinformatics. 2012 May 08;13:86
pubmed: 22568884
Aging Cell. 2012 Aug;11(4):694-703
pubmed: 22621408
PLoS One. 2012;7(7):e41361
pubmed: 22848472
BMC Genomics. 2013 May 01;14:293
pubmed: 23631413
Genome Biol. 2013 May 22;14(5):R42
pubmed: 23697701
Curr Pharm Des. 2014;20(11):1726-50
pubmed: 23888966
Best Pract Res Clin Obstet Gynaecol. 2013 Dec;27(6):791-802
pubmed: 24012425
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Hum Mol Genet. 2014 Mar 1;23(5):1186-201
pubmed: 24163245
Eur Rev Med Pharmacol Sci. 2013 Nov;17(22):3083-94
pubmed: 24302191
Genome Res. 2014 Nov;24(11):1725-33
pubmed: 25249537
Cancer Epidemiol Biomarkers Prev. 2015 Jan;24(1):221-9
pubmed: 25371448
Genome Biol. 2015 Feb 15;16:37
pubmed: 25853392
Clin Epigenetics. 2015 Mar 26;7:34
pubmed: 25874017
BMC Bioinformatics. 2015 Apr 28;16:131
pubmed: 25928765
Biomed Res Int. 2015;2015:730535
pubmed: 26180810
Nucleic Acids Res. 2016 Feb 18;44(3):e20
pubmed: 26384415
Mol Cell Biochem. 2016 May;416(1-2):1-9
pubmed: 27023910
J Clin Endocrinol Metab. 2016 Jun;101(6):2432-9
pubmed: 27049477
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Dis Markers. 2016;2016:3841927
pubmed: 27313333
Genom Data. 2016 May 26;9:22-4
pubmed: 27330998
Nature. 2017 Jan 5;541(7635):81-86
pubmed: 28002404
BMC Genomics. 2017 Jan 5;18(1):25
pubmed: 28056824
J Obstet Gynaecol. 2017 Jul;37(5):571-575
pubmed: 28604181
J Intern Med. 2017 Oct;282(4):298-309
pubmed: 28688111
Genet Epigenet. 2017 Jul 28;9:1179237X17721540
pubmed: 28811741
Mech Ageing Dev. 2018 Sep;174:3-17
pubmed: 29268958
Arterioscler Thromb Vasc Biol. 2018 Mar;38(3):645-652
pubmed: 29326313
Acta Paediatr. 2018 Jun;107(6):1003-1010
pubmed: 29385276
Int J Epidemiol. 2018 Aug 1;47(4):1043-1044i
pubmed: 29547889