The effects of zingerone against vancomycin-induced lung, liver, kidney and testis toxicity in rats: The behavior of some metabolic enzymes.
acetylcholinesterase
aldose reductase
carbonic anhydrase
vancomycin
zingerone
Journal
Journal of biochemical and molecular toxicology
ISSN: 1099-0461
Titre abrégé: J Biochem Mol Toxicol
Pays: United States
ID NLM: 9717231
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
04
02
2019
revised:
04
07
2019
accepted:
17
07
2019
pubmed:
28
8
2019
medline:
18
12
2019
entrez:
28
8
2019
Statut:
ppublish
Résumé
In this study, it was demonstrated the ameliorative effect of zingerone (ZO) (25 and 50 mg/kg body weight) against vancomycin (VCM) (200 mg/kg body weight) administered to rats on some metabolic enzymes' activities in the lung, liver, kidney, and testis tissues of rats. Forty-two rats were divided into six groups as follows: control, ZO-25, ZO-50, VCM, VCM + ZO-25, and VCM + ZO-50. α-Glycosidase, butyrylcholinesterase, aldose reductase, acetylcholinesterase, paraoxonase-1, and carbonic anhydrase enzyme activities were significantly (P < .05) decreased in VCM group when compared with the control group. ZO, supplied with VCM, significantly activated some of these enzyme in all tissues. The results of this study showed that ZO regulates abnormal increases and decreases in VCM-induced metabolic enzyme activities in all tissues.
Substances chimiques
Enzymes
0
zingerone
4MMW850892
Guaiacol
6JKA7MAH9C
Vancomycin
6Q205EH1VU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e22381Subventions
Organisme : Ataturk University, Foundation of Scientific Research Projects
ID : PRJ2016/74
Informations de copyright
© 2019 Wiley Periodicals, Inc.