PET/MRI in large-vessel vasculitis: clinical value for diagnosis and assessment of disease activity.
Adult
Aged
Aged, 80 and over
Female
Fibrosis
Fluorodeoxyglucose F18
/ chemistry
Giant Cell Arteritis
/ diagnosis
Humans
Image Processing, Computer-Assisted
Inflammation
/ complications
Magnetic Resonance Imaging
Male
Middle Aged
Positron-Emission Tomography
Recurrence
Retrospective Studies
Takayasu Arteritis
/ diagnosis
Young Adult
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
27 08 2019
27 08 2019
Historique:
received:
20
02
2019
accepted:
23
07
2019
entrez:
29
8
2019
pubmed:
29
8
2019
medline:
30
10
2020
Statut:
epublish
Résumé
Diagnosis of large vessel vasculitis (LVV) and evaluation of its inflammatory activity can be challenging. Our aim was to investigate the value of hybrid positron-emission tomography/magnetic resonance imaging (PET/MRI) in LVV. All consecutive patients with LVV from the Department of Internal Medicine who underwent PET/MRI were included. Three PET/MRI patterns were defined: (i) "inflammatory," with positive PET (>liver uptake) and abnormal MRI (stenosis and/or wall thickening); (ii) "fibrous", negative PET (≤liver uptake) and abnormal MRI; and (iii) "normal". Thirteen patients (10 female; median age: 67-years [range: 23-87]) underwent 18 PET/MRI scans. PET/MRI was performed at diagnosis (n = 4), at relapse (n = 7), or during remission (n = 7). Among the 18 scans, eight (44%) showed an inflammatory pattern and three (17%) a fibrous pattern; the other seven were normal. The distribution of the three patterns did not differ between patients with Takayasu arteritis (TA, n = 10 scans) and those with giant cell arteritis (GCA, n = 8 scans). PET/MRI findings were normal in 2/10 (20%) TA scans vs. 5/8 (62%) GCA scans (p = 0.3). Median SUV
Identifiants
pubmed: 31455785
doi: 10.1038/s41598-019-48709-w
pii: 10.1038/s41598-019-48709-w
pmc: PMC6711961
doi:
Substances chimiques
Fluorodeoxyglucose F18
0Z5B2CJX4D
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12388Références
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