Chronic myeloid leukemia: the concepts of resistance and persistence and the relationship with the BCR-ABL1 transcript type.

Antineoplastic Agents / therapeutic use Drug Resistance, Neoplasm / drug effects Fusion Proteins, bcr-abl / genetics Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive / drug therapy Protein Kinase Inhibitors / therapeutic use Quality of Life

Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
10 2019
Historique:
received: 24 04 2019
accepted: 03 07 2019
revised: 04 06 2019
pubmed: 29 8 2019
medline: 6 2 2020
entrez: 29 8 2019
Statut: ppublish

Résumé

Chronic myeloid leukemia is driven by a hybrid gene, BCR-ABL1, that codes for a leukemogenic tyrosine kinase (TK) protein of 210 KDa (p210

Identifiants

DOI: 10.1038/s41375-019-0562-1 PMID: 31455852
pubmed: 31455852
doi: 10.1038/s41375-019-0562-1
pii: 10.1038/s41375-019-0562-1
doi:

Substances chimiques

Antineoplastic Agents 0
Protein Kinase Inhibitors 0
Fusion Proteins, bcr-abl EC 2.7.10.2

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

2358-2364

Auteurs

Michele Baccarani (M)

Institute of Hematology "Lorenzo and Ariosto Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy. michele.baccarani@unibo.it.

Gianantonio Rosti (G)

Institute of Hematology "Lorenzo and Ariosto Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.

Simona Soverini (S)

Institute of Hematology "Lorenzo and Ariosto Seràgnoli", Department of Experimental, Diagnostic and Specialty Medicine, S.Orsola-Malpighi University Hospital, University of Bologna, Bologna, Italy.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Chronic myeloid leukemia: the concepts of...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance aux médicaments antinéoplasiques › Chronic myeloid leukemia: the concepts of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-bcr › Protéines de fusion bcr-abl › Chronic myeloid leukemia: the concepts of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Chronic myeloid leukemia: the concepts of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Leucémie myéloïde chronique BCR-ABL positive › Chronic myeloid leukemia: the concepts of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de protéines kinases › Chronic myeloid leukemia: the concepts of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Mesures épidémiologiques › Démographie › État de santé › Qualité de vie › Chronic myeloid leukemia: the concepts of...