High prevalence of urogenital infection/inflammation in patients with azoospermia does not impede surgical sperm retrieval.
Adult
Azoospermia
/ immunology
Bacteria
/ isolation & purification
Biopsy
Humans
Male
Prevalence
Prospective Studies
Retrospective Studies
Semen Analysis
Sperm Retrieval
/ statistics & numerical data
Testis
/ immunology
Treatment Outcome
Urinary Tract Infections
/ diagnosis
Viruses
/ isolation & purification
TESE
azoospermia
genital tract inflammation
infertility
male accessory gland infection
Journal
Andrologia
ISSN: 1439-0272
Titre abrégé: Andrologia
Pays: Germany
ID NLM: 0423506
Informations de publication
Date de publication:
Nov 2019
Nov 2019
Historique:
received:
04
06
2019
revised:
21
07
2019
accepted:
22
07
2019
pubmed:
29
8
2019
medline:
3
4
2020
entrez:
29
8
2019
Statut:
ppublish
Résumé
Considering infection/inflammation to be an important risk factor in male infertility, the aim of this study was to make a comprehensive evaluation of the prevalence of urogenital tract infection/inflammation and its potential impact on sperm retrieval in azoospermic patients. In this prospective study, 71 patients with azoospermia were subjected to an extensive andrological workup including comprehensive microbiological diagnostics (2-glass test, semen, testicular swab and testicular tissue analysis) and testicular biopsy/testicular sperm extraction (TESE). Medical history suggested urogenital tract infection/inflammation in 7% of patients, 11% harboured STIs, 14% showed significant bacteriospermia, 15% had seminal inflammation, 17% fulfilled the MAGI definition, and 27% had relevant pathogens. At the testicular level, 1 patient had a swab positive for bacteria, no viruses were detected, tissue specimens never indicated pathogens, whereas histopathology revealed focal immune cell infiltrates in 23% of samples. Testicular sperm retrieval rate was 100% in obstructive and 46% in nonobstructive azoospermia. None of the infection/inflammation-related variables was associated with the success of sperm retrieval or inflammatory lesions in the testis. The high prevalence of urogenital infection/inflammation among azoospermic men underpins their role as significant aetiologic factors in male infertility. However, this observation does not refer to the chances of sperm retrieval at the time of surgery/TESE.
Identifiants
pubmed: 31456226
doi: 10.1111/and.13401
pmc: PMC7147116
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13401Subventions
Organisme : This work was supported by the LOEWE focus group MIBIE (Male Infertility during Infection and Inflammation, projects B1, C1, C2, and C3, state government of Hessen, Germany). None of those who provided funds had a role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Informations de copyright
© 2019 The Authors. Andrologia published by Blackwell Verlag GmbH.
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