FSH receptor binding inhibitor depresses carcinogenesis of ovarian cancer via decreasing levels of K-Ras, c-Myc and FSHR.

Animals Female Oocytes / chemistry Ovarian Neoplasms / metabolism Proto-Oncogene Proteins c-myc / metabolism Proto-Oncogene Proteins p21(ras) / metabolism Receptors, FSH / antagonists & inhibitors Sheep
FSH receptor binding inhibitor K-Ras Oocyte Ovarian cancer Signal pathway c-Myc

Journal

Animal biotechnology
ISSN: 1532-2378
Titre abrégé: Anim Biotechnol
Pays: England
ID NLM: 9011409

Informations de publication

Date de publication:
Feb 2021
Historique:
pubmed: 29 8 2019
medline: 12 10 2021
entrez: 29 8 2019
Statut: ppublish

Résumé

The present study aimed to explore FSH receptor binding inhibitor (FRBI) effects on the levels of c-Myc, K-Ras and VEGF related to ovarian cancer, to evaluate the mRNA and protein levels of FSHR in the cumulus-oocyte complex (COCs). COCs were cultured for 24 h in the

Identifiants

DOI: 10.1080/10495398.2019.1656083 PMID: 31456468
pubmed: 31456468
doi: 10.1080/10495398.2019.1656083
doi:

Substances chimiques

Proto-Oncogene Proteins c-myc 0
Receptors, FSH 0
Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

84-91

Auteurs

Juan Yang (J)

College of Life Science and Engineering, Northwest Minzu University, Lanzhou, Gansu, P. R. China.

Zhuandi Gong (Z)

Hospital of Medicine College, Northwest Minzu University, Lanzhou, Gansu, P. R. China.

Xiaoyun Shen (X)

State Engineering Technology Institute for Karst Desertification Control, Guizhou Normal University, Guiyang, Guizhou, P. R. China.
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang, Sichuan, P. R. China.

Shengju Bai (S)

College of Life Science and Engineering, Northwest Minzu University, Lanzhou, Gansu, P. R. China.

Xiaoqiang Bai (X)

College of Life Science and Engineering, Northwest Minzu University, Lanzhou, Gansu, P. R. China.

Suocheng Wei (S)

College of Life Science and Engineering, Northwest Minzu University, Lanzhou, Gansu, P. R. China.
Hospital of Medicine College, Northwest Minzu University, Lanzhou, Gansu, P. R. China.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › FSH receptor binding inhibitor depresses...
questionsmedicales.fr › Cellules › Cellules germinales › Ovocytes › FSH receptor binding inhibitor depresses...
questionsmedicales.fr › Maladies endocriniennes › Troubles gonadiques › Maladies ovariennes › Tumeurs de l'ovaire › FSH receptor binding inhibitor depresses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Protéines proto-oncogènes c-myc › FSH receptor binding inhibitor depresses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes p21(ras) › FSH receptor binding inhibitor depresses...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur hormone hypophysaire › Récepteur gonadotrophine › Récepteur FSH › FSH receptor binding inhibitor depresses...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Ovis › FSH receptor binding inhibitor depresses...