The Effect of Antioxidants on the Properties of Red Blood Cells From Patients With Sickle Cell Anemia.
K+ permeability
N-acetylcysteine
antioxidant
dithiothreitol
phosphatidylserine exposure
quercetin
sickle cell
sickling
Journal
Frontiers in physiology
ISSN: 1664-042X
Titre abrégé: Front Physiol
Pays: Switzerland
ID NLM: 101549006
Informations de publication
Date de publication:
2019
2019
Historique:
received:
02
05
2019
accepted:
11
07
2019
entrez:
29
8
2019
pubmed:
29
8
2019
medline:
29
8
2019
Statut:
epublish
Résumé
Oxidative damage to red blood cells (RBCs) may contribute to pathogenesis of sickle cell anemia. Reducing the deleterious effects of oxidants by exposing RBCs to a number of antioxidants has been shown to have protective effects against lipid and protein peroxidation. We hypothesize that antioxidants may also have beneficial effects on the abnormal membrane permeability of sickle cells. Increased cation permeability of these cells encourages HbS polymerization by causing RBC dehydration and also leads to externalization of the prothrombotic aminophospholipid phosphatidylserine (PS). Three antioxidants with different mechanisms of action were investigated - dithiothreitol,
Identifiants
pubmed: 31456691
doi: 10.3389/fphys.2019.00976
pmc: PMC6700761
doi:
Types de publication
Journal Article
Langues
eng
Pagination
976Subventions
Organisme : British Heart Foundation
ID : PG/15/118/31966
Pays : United Kingdom
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