Evidence of a Demethylase-Independent Role for the H3K4-Specific Histone Demethylases in
Aspergillus nidulans
CclA
Fusarium graminearum
H3K4 methylation
KDM5
SppA
histone demethylase
secondary metabolism
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
08
05
2019
accepted:
16
07
2019
entrez:
29
8
2019
pubmed:
29
8
2019
medline:
29
8
2019
Statut:
epublish
Résumé
Fungi produce a plethora of secondary metabolites (SMs) involved in cellular protection, defense, and signaling. Like other metabolic processes, transcription of SM biosynthesis genes is tightly regulated to prevent an unnecessary use of resources. Genes involved in SM biosynthesis are usually physically linked, arranged in secondary metabolite gene clusters (SMGCs). Research over the last decades has shown that chromatin structure and posttranslational modifications (PTMs) of histones represent important layers of SMGC regulation. For instance, trimethylation of histone H3 lysine 4 (H3K4me3) is a PTM typically associated with promoter regions of actively transcribed genes. Previously, we have shown that the H3K4me3-specific, JmjC domain-containing histone demethylase KdmB functions not only in repression but also in activation of secondary metabolism in
Identifiants
pubmed: 31456754
doi: 10.3389/fmicb.2019.01759
pmc: PMC6700381
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1759Subventions
Organisme : Austrian Science Fund FWF
ID : M 2149
Pays : Austria
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