Dietary Supplementation With Leucine or in Combination With Arginine Decreases Body Fat Weight and Alters Gut Microbiota Composition in Finishing Pigs.
arginine
colon
dietary supplementation
glutamic acid
leucine
microbiota
short-chain fatty acid
Journal
Frontiers in microbiology
ISSN: 1664-302X
Titre abrégé: Front Microbiol
Pays: Switzerland
ID NLM: 101548977
Informations de publication
Date de publication:
2019
2019
Historique:
received:
06
04
2019
accepted:
17
07
2019
entrez:
29
8
2019
pubmed:
29
8
2019
medline:
29
8
2019
Statut:
epublish
Résumé
Obesity was associated with change in gut microbiota composition and their metabolites. We investigated the effects of dietary supplementation with leucine (Leu) in combination with arginine (Arg) or glutamic acid (Glu) on body fat weight, composition of gut microbiota, and short-chain fatty acids (SCFAs) concentration in the colon. Forty-eight Duroc × Large White × Landrace pigs with an initial body weight of 77.08 ± 1.29 kg were randomly assigned to one of the four groups (12 pigs per group). The pigs in the control group were fed a basal diet supplemented with 2.05% alanine (isonitrogenous control, BD group), and those in the three experimental groups were fed a basal diet supplemented with 1.00% Leu + 1.37% alanine (Leu group), 1.00% Leu + 1.00% Arg (Leu_Arg group), or 1.00% Leu + 1.00% Glu (Leu_Glu group). We found that dietary supplementation with Leu alone or in combination with Arg decreased (
Identifiants
pubmed: 31456756
doi: 10.3389/fmicb.2019.01767
pmc: PMC6700229
doi:
Types de publication
Journal Article
Langues
eng
Pagination
1767Références
Physiol Rev. 2001 Jul;81(3):1031-64
pubmed: 11427691
J Physiol. 2001 Nov 1;536(Pt 3):871-7
pubmed: 11691879
Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):11070-5
pubmed: 16033867
J Nutr Biochem. 2006 Sep;17(9):571-88
pubmed: 16524713
Nutrition. 2006 May;22(5):520-7
pubmed: 16600817
Nature. 2006 Dec 21;444(7122):1027-31
pubmed: 17183312
Diabetes. 2007 Jun;56(6):1647-54
pubmed: 17360978
J Nutr. 2007 Dec;137(12):2680-5
pubmed: 18029483
Amino Acids. 2009 May;37(1):169-75
pubmed: 18683021
Int J Obes (Lond). 2008 Nov;32(11):1720-4
pubmed: 18779823
Nature. 2009 Jan 22;457(7228):480-4
pubmed: 19043404
Diabetes. 2009 Jul;58(7):1509-17
pubmed: 19366864
Nutr Metab (Lond). 2010 Jul 12;7:57
pubmed: 20624298
Proc Natl Acad Sci U S A. 2011 May 10;108(19):8030-5
pubmed: 21518883
Nutrition. 2012 Feb;28(2):182-9
pubmed: 21872432
Bioinformatics. 2011 Nov 1;27(21):2957-63
pubmed: 21903629
PLoS One. 2012;7(4):e35240
pubmed: 22506074
J Neuroendocrinol. 2012 Oct;24(10):1356-64
pubmed: 22612562
Nutrients. 2012 Jun;4(6):529-41
pubmed: 22822451
Am J Physiol Endocrinol Metab. 2012 Nov 15;303(10):E1234-44
pubmed: 22967499
Lancet. 2012 Dec 15;380(9859):2224-60
pubmed: 23245609
PLoS One. 2013;8(2):e56612
pubmed: 23437186
Sci Transl Med. 2013 Mar 27;5(178):178ra41
pubmed: 23536013
Nat Methods. 2013 Oct;10(10):996-8
pubmed: 23955772
Int J Obes (Lond). 2014 Dec;38(12):1525-31
pubmed: 24642959
J Nutr. 2014 Jun;144(6):988-95
pubmed: 24670969
Bioinformatics. 2014 Aug 1;30(15):2114-20
pubmed: 24695404
Gut. 2015 Nov;64(11):1744-54
pubmed: 25500202
Diabetes. 2015 Jul;64(7):2398-408
pubmed: 25695945
Obes Facts. 2015;8(2):87-100
pubmed: 25791341
World J Gastrointest Pathophysiol. 2015 Nov 15;6(4):110-9
pubmed: 26600968
Obes Rev. 2016 Feb;17(2):95-107
pubmed: 26696565
Front Microbiol. 2016 Feb 17;7:185
pubmed: 26925050
Trends Pharmacol Sci. 2016 Aug;37(8):714-727
pubmed: 27256112
Mol Nutr Food Res. 2016 Dec;60(12):2611-2621
pubmed: 27467905
Oncotarget. 2016 Aug 30;7(35):56071-56082
pubmed: 27528227
J Anim Sci. 2017 Jun;95(6):2680-2689
pubmed: 28727042
Front Microbiol. 2017 Oct 06;8:1929
pubmed: 29056930
J Anim Sci. 2017 Dec;95(12):5507-5515
pubmed: 29293787
J Anim Sci Biotechnol. 2018 Jan 30;9:18
pubmed: 29423216
JAMA. 2018 Apr 24;319(16):1723-1725
pubmed: 29570750
Nat Rev Endocrinol. 2018 Jun;14(6):356-376
pubmed: 29686432
J Anim Physiol Anim Nutr (Berl). 2019 May;103(3):791-800
pubmed: 30815917
Yale J Biol Med. 1979 May-Jun;52(3):307-29
pubmed: 380187