LAV-BPIFB4 associates with reduced frailty in humans and its transfer prevents frailty progression in old mice.
BPIFB4
aging
frailty
longevity-associated variant-lav
survival
Journal
Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617
Informations de publication
Date de publication:
28 08 2019
28 08 2019
Historique:
received:
27
06
2019
accepted:
12
08
2019
pubmed:
29
8
2019
medline:
4
9
2020
entrez:
29
8
2019
Statut:
ppublish
Résumé
There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human These data indicate that specific BPIFB4 haplotypes could represent useful genetic markers of frailty. In addition, horizontal transfer of a healthy gene variant can attenuate frailty in aging organisms.
Sections du résumé
BACKGROUND
There is an increasing concern about age-related frailty because of the growing number of elderly people in the general population. The Longevity-Associated Variant (LAV) of the human
CONCLUSIONS
These data indicate that specific BPIFB4 haplotypes could represent useful genetic markers of frailty. In addition, horizontal transfer of a healthy gene variant can attenuate frailty in aging organisms.
Identifiants
pubmed: 31461407
pii: 102209
doi: 10.18632/aging.102209
pmc: PMC6738439
doi:
Substances chimiques
BPIFB4 protein, human
0
Intercellular Signaling Peptides and Proteins
0
Phosphoproteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
6555-6568Subventions
Organisme : British Heart Foundation
ID : PG/18/66/33838
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
Références
Age (Dordr). 2012 Jun;34(3):571-82
pubmed: 21567248
Eur Heart J. 2019 Jul 10;:
pubmed: 31289820
Circ Res. 2015 Jul 31;117(4):333-45
pubmed: 26034043
Aging (Albany NY). 2017 Jan 22;9(2):370-380
pubmed: 28121621
Biogerontology. 2016 Aug;17(4):703-14
pubmed: 26820297
J Gerontol A Biol Sci Med Sci. 2019 Nov 13;74(Supplement_1):S38-S44
pubmed: 31074771
Age (Dordr). 2010 Sep;32(3):385-95
pubmed: 20640550
Bio Protoc. 2017 Apr 20;7(8):
pubmed: 28713848
Age (Dordr). 2014 Feb;36(1):495-505
pubmed: 23959520
Aging (Albany NY). 2018 Dec 18;10(12):4042-4053
pubmed: 30562163
Int J Mol Sci. 2018 Oct 19;19(10):
pubmed: 30347645
J Neurosci Methods. 2002 Jan 30;113(2):123-30
pubmed: 11772434
J Am Heart Assoc. 2012 Aug;1(4):e001081
pubmed: 23130158
CMAJ. 2005 Aug 30;173(5):489-95
pubmed: 16129869
J Gerontol A Biol Sci Med Sci. 2017 Jul 1;72(7):904-909
pubmed: 28549083
BMC Nephrol. 2015 Sep 23;16:157
pubmed: 26395776
Sci Rep. 2017 Aug 29;7(1):9706
pubmed: 28852218
Arch Public Health. 2015 Apr 10;73(1):19
pubmed: 25866625
J Gerontol A Biol Sci Med Sci. 2014 Dec;69(12):1485-91
pubmed: 24336799
J Gerontol A Biol Sci Med Sci. 2004 Mar;59(3):255-63
pubmed: 15031310
Rejuvenation Res. 2017 Dec;20(6):517-524
pubmed: 28602121
Ageing Res Rev. 2016 Nov;31:1-8
pubmed: 27592340
Longev Healthspan. 2013 Sep 16;2(1):14
pubmed: 24472376
Diseases. 2019 Feb 02;7(1):
pubmed: 30717332
J Vis Exp. 2013 Jun 02;(76):
pubmed: 23770643
J Nutr Health Aging. 2015 Dec;19(10):1043-8
pubmed: 26624218
Cell Metab. 2018 Mar 6;27(3):667-676.e4
pubmed: 29514072
Rejuvenation Res. 2011 Jun;14(3):283-91
pubmed: 21612516
J Am Geriatr Soc. 2010 Apr;58(4):681-7
pubmed: 20345864
J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56
pubmed: 11253156
Comp Immunol Microbiol Infect Dis. 2019 Apr;63:1-9
pubmed: 30961802
J Gerontol A Biol Sci Med Sci. 2015 Jun;70(6):686-93
pubmed: 25205762
Immun Ageing. 2015 Dec 15;12:27
pubmed: 26675039
Mech Ageing Dev. 2012 Jun;133(6):456-66
pubmed: 22663935
J Gerontol A Biol Sci Med Sci. 2014 Jun;69(6):621-32
pubmed: 24051346