The Influence of Bee Venom Melittin on the Functioning of the Immune System and the Contractile Activity of the Insect Heart-A Preliminary Study.
Animals
Apoptosis
/ drug effects
Bee Venoms
/ chemistry
Dose-Response Relationship, Drug
Heart
/ drug effects
Hemocytes
/ drug effects
Immune System
/ drug effects
Male
Melitten
/ isolation & purification
Models, Animal
Myocardial Contraction
/ drug effects
Phagocytosis
/ drug effects
Tenebrio
/ drug effects
Tenebrio molitor
apoptosis
heart contractility
insect immune system
melittin
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
27 08 2019
27 08 2019
Historique:
received:
23
07
2019
revised:
20
08
2019
accepted:
23
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Melittin (MEL) is a basic polypeptide originally purified from honeybee venom. MEL exhibits a broad spectrum of biological activity. However, almost all studies on MEL activity have been carried out on vertebrate models or cell lines. Recently, due to cheap breeding and the possibility of extrapolating the results of the research to vertebrates, insects have been used for various bioassays and comparative physiological studies. For these reasons, it is valuable to examine the influence of melittin on insect physiology. Here, for the first time, we report the immunotropic and cardiotropic effects of melittin on the beetle
Identifiants
pubmed: 31461888
pii: toxins11090494
doi: 10.3390/toxins11090494
pmc: PMC6784010
pii:
doi:
Substances chimiques
Bee Venoms
0
Melitten
20449-79-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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