CTCs 2020: Great Expectations or Unreasonable Dreams.
CTC
clinical utility
heterogeneity
liquid biopsy
liquid surgery
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
27 08 2019
27 08 2019
Historique:
received:
19
07
2019
revised:
20
08
2019
accepted:
22
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
14
5
2020
Statut:
epublish
Résumé
Circulating tumor cells (CTCs) are cellular elements that can be scattered into the bloodstream from primary cancer, metastasis, and even from a disseminated tumor cell (DTC) reservoir. CTCs are "seeds", able to give rise to new metastatic lesions. Since metastases are the cause of about 90% of cancer-related deaths, the significance of CTCs is unquestionable. However, two major issues have stalled their full clinical exploitation: rarity and heterogeneity. Therefore, their full clinical potential has only been predicted. Finding new ways of studying and using such tremendously rare and important events can open new areas of research in the field of cancer research, and could drastically improve tumor companion diagnostics, personalized treatment strategies, overall patients management, and reduce healthcare costs.
Identifiants
pubmed: 31461978
pii: cells8090989
doi: 10.3390/cells8090989
pmc: PMC6769853
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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