Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination.
endothelial disorders
glycocalyx injury
nonlinear regression
syndecan-1
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
27 Aug 2019
27 Aug 2019
Historique:
received:
27
06
2019
revised:
20
08
2019
accepted:
24
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
30
8
2019
Statut:
epublish
Résumé
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (
Identifiants
pubmed: 31462009
pii: jcm8091320
doi: 10.3390/jcm8091320
pmc: PMC6780947
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Japan Society for the Promotion of Science
ID : 19H03756
Organisme : Japan Society for the Promotion of Science
ID : 19K09410
Organisme : Japan Society for the Promotion of Science
ID : 19K18347
Organisme : Japan Society for the Promotion of Science
ID : 18K08914
Organisme : Japan Society for the Promotion of Science
ID : 18K08884
Organisme : Japan Society for the Promotion of Science
ID : 18K16511
Organisme : Japan Society for the Promotion of Science
ID : 18K16533
Organisme : Japan Society for the Promotion of Science
ID : 17K11569
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