Regulation of Stress Granule Formation by Inflammation, Vascular Injury, and Atherosclerosis.
Animals
Atherosclerosis
/ metabolism
Biopsy, Needle
Cells, Cultured
Cholesterol
/ pharmacology
Cytoplasmic Granules
/ genetics
DNA Helicases
/ genetics
Disease Models, Animal
Gene Expression Regulation
Humans
Immunohistochemistry
Male
Mice
Mice, Inbred C57BL
Muscle, Smooth, Vascular
/ cytology
Oxidative Stress
Poly-ADP-Ribose Binding Proteins
/ genetics
RNA Helicases
/ genetics
RNA Recognition Motif Proteins
/ genetics
Random Allocation
Sensitivity and Specificity
Vascular System Injuries
/ metabolism
atherosclerosis
mice
muscle, smooth, vascular
oxidative stress
vascular diseases
Journal
Arteriosclerosis, thrombosis, and vascular biology
ISSN: 1524-4636
Titre abrégé: Arterioscler Thromb Vasc Biol
Pays: United States
ID NLM: 9505803
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
pubmed:
30
8
2019
medline:
19
3
2020
entrez:
30
8
2019
Statut:
ppublish
Résumé
Stress granules (SGs) are dynamic cytoplasmic aggregates containing mRNA, RNA-binding proteins, and translation factors that form in response to cellular stress. SGs have been shown to contribute to the pathogenesis of several human diseases, but their role in vascular diseases is unknown. This study shows that SGs accumulate in vascular smooth muscle cells (VSMCs) and macrophages during atherosclerosis. Approach and Results: Immunohistochemical analysis of atherosclerotic plaques from LDLR These results indicate that SG formation is a common feature of the vascular response to injury and disease, and that modification of inflammation reduces stress granule formation in VSMC.
Identifiants
pubmed: 31462091
doi: 10.1161/ATVBAHA.119.313034
pmc: PMC6761003
mid: NIHMS1537613
doi:
Substances chimiques
Poly-ADP-Ribose Binding Proteins
0
RNA Recognition Motif Proteins
0
Cholesterol
97C5T2UQ7J
DNA Helicases
EC 3.6.4.-
G3BP1 protein, human
EC 3.6.4.12
RNA Helicases
EC 3.6.4.13
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2014-2027Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL131481
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL141108
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL117724
Pays : United States
Organisme : NHLBI NIH HHS
ID : R35 HL135799
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL131478
Pays : United States
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