Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy.
Cancer immunotherapy
Cancer-associated fibroblasts
Heterogeneity
Immune suppression
Journal
Journal of hematology & oncology
ISSN: 1756-8722
Titre abrégé: J Hematol Oncol
Pays: England
ID NLM: 101468937
Informations de publication
Date de publication:
28 08 2019
28 08 2019
Historique:
received:
15
06
2019
accepted:
12
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
1
8
2020
Statut:
epublish
Résumé
Among all the stromal cells that present in the tumor microenvironment, cancer-associated fibroblasts (CAFs) are one of the most abundant and critical components of the tumor mesenchyme, which not only provide physical support for tumor cells but also play a key role in promoting and retarding tumorigenesis in a context-dependent manner. CAFs have also been involved in the modulation of many components of the immune system, and recent studies have revealed their roles in immune evasion and poor responses to cancer immunotherapy. In this review, we describe our current understanding of the tumorigenic significance, origin, and heterogeneity of CAFs, as well as the roles of different CAFs subtypes in distinct immune cell types. More importantly, we highlight potential therapeutic strategies that target CAFs to unleash the immune system against the tumor.
Identifiants
pubmed: 31462327
doi: 10.1186/s13045-019-0770-1
pii: 10.1186/s13045-019-0770-1
pmc: PMC6714445
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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