Evolutionary Dynamics in Structured Populations Under Strong Population Genetic Forces.
Algorithms
Animals
Bayes Theorem
Biological Evolution
Drug Resistance, Viral
Evolution, Molecular
Genetic Variation
Genetics, Population
Humans
Models, Genetic
Models, Statistical
Population Dynamics
Selection, Genetic
Simian Acquired Immunodeficiency Syndrome
/ virology
Simian Immunodeficiency Virus
/ drug effects
FST
Migration
Rapid adaptation
Simian-HIV
Spatial structure
approximate Bayesian computation
Journal
G3 (Bethesda, Md.)
ISSN: 2160-1836
Titre abrégé: G3 (Bethesda)
Pays: England
ID NLM: 101566598
Informations de publication
Date de publication:
07 10 2019
07 10 2019
Historique:
pubmed:
30
8
2019
medline:
13
3
2020
entrez:
30
8
2019
Statut:
epublish
Résumé
In the long-term neutral equilibrium, high rates of migration between subpopulations result in little population differentiation. However, in the short-term, even very abundant migration may not be enough for subpopulations to equilibrate immediately. In this study, we investigate dynamical patterns of short-term population differentiation in adapting populations via stochastic and analytical modeling through time. We characterize a regime in which selection and migration interact to create non-monotonic patterns of population differentiation over time when migration is weaker than selection, but stronger than drift. We demonstrate how these patterns can be leveraged to estimate high migration rates using approximate Bayesian computation. We apply this approach to estimate fast migration in a rapidly adapting intra-host Simian-HIV population sampled from different anatomical locations. We find differences in estimated migration rates between different compartments, even though all are above [Formula: see text] = 1. This work demonstrates how studying demographic processes on the timescale of selective sweeps illuminates processes too fast to leave signatures on neutral timescales.
Identifiants
pubmed: 31462443
pii: g3.119.400605
doi: 10.1534/g3.119.400605
pmc: PMC6778802
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3395-3407Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM118165
Pays : United States
Informations de copyright
Copyright © 2019 Feder et al.
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