Prenatal Opioid Exposure: Neurodevelopmental Consequences and Future Research Priorities.
Journal
Pediatrics
ISSN: 1098-4275
Titre abrégé: Pediatrics
Pays: United States
ID NLM: 0376422
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
accepted:
22
05
2019
pubmed:
30
8
2019
medline:
17
1
2020
entrez:
30
8
2019
Statut:
ppublish
Résumé
Neonatal opioid withdrawal syndrome (NOWS) has risen in prevalence from 1.2 per 1000 births in 2000 to 5.8 per 1000 births in 2012. Symptoms in neonates may include high-pitched cry, tremors, feeding difficulty, hypertonia, watery stools, and breathing problems. However, little is known about the neurodevelopmental consequences of prenatal opioid exposure in infancy, early childhood, and middle childhood. Even less is known about the cognitive, behavioral, and academic outcomes of children who develop NOWS. We review the state of the literature on the neurodevelopmental consequences of prenatal opioid exposure with a particular focus on studies in which NOWS outcomes were examined. Aiming to reduce the incidence of prenatal opioid exposure in the near future, we highlight the need for large studies with prospectively recruited participants and longitudinal designs, taking into account confounding factors such as socioeconomic status, institutional variations in care, and maternal use of other substances, to independently assess the full impact of NOWS. As a more immediate solution, we provide an agenda for future research that leverages the National Institutes of Health Environmental Influences on Child Health Outcomes program to address many of the serious methodologic gaps in the literature, and we answer key questions regarding the short- and long-term neurodevelopmental health of children with prenatal opioid exposure.
Identifiants
pubmed: 31462446
pii: peds.2019-0128
doi: 10.1542/peds.2019-0128
pmc: PMC6759228
mid: NIHMS1051239
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : UH3 OD023389
Pays : United States
Organisme : NIH HHS
ID : U2C OD023375
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023320
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023271
Pays : United States
Organisme : NIH HHS
ID : UG1 OD024958
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023347
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023289
Pays : United States
Organisme : NICHD NIH HHS
ID : UG1 HD090848
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA049755
Pays : United States
Organisme : NIH HHS
ID : U24 OD023382
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023289
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023271
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023328
Pays : United States
Organisme : NIH HHS
ID : UG1 OD024942
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023389
Pays : United States
Organisme : NIDA NIH HHS
ID : K08 DA038959
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023320
Pays : United States
Organisme : NIH HHS
ID : UG3 OD023249
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023328
Pays : United States
Informations de copyright
Copyright © 2019 by the American Academy of Pediatrics.
Déclaration de conflit d'intérêts
POTENTIAL CONFLICT OF INTEREST: The authors have indicated they have no potential conflicts of interest to disclose.
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