Pre-induction fentanyl dose-finding study for controlled hypotension during functional endoscopic sinus surgery.
Controlled hypotension
endoscopy
fentanyl
paranasal sinuses
surgery
Journal
Indian journal of anaesthesia
ISSN: 0019-5049
Titre abrégé: Indian J Anaesth
Pays: India
ID NLM: 0013243
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
30
8
2019
Statut:
ppublish
Résumé
Fentanyl can facilitate controlled intraoperative hypotension by its sympatholytic effect in patients undergoing functional endoscopic sinus surgery (FESS). We investigated the effects of different doses of pre-induction fentanyl on controlled hypotension profile during FESS. This prospective, randomised study included 120 patients randomly allocated to three groups (40 each) based on administration of pre-induction fentanyl; 2 μg/kg group, 3 μg/kg group and 4 μg/kg group. The primary objective was to assess effect on intraoperative heart rate and mean arterial pressure. Use of additional hypotensive agents, surgical field condition and surgeon satisfaction were also analysed. Controlled hypotension was achieved adequately in all participants. Patients belonging to fentanyl 4 μg/kg group had significantly lower heart rate for the duration of controlled hypotension intraoperatively versus fentanyl 2 μg/kg group ( Pre-induction fentanyl 3 μg/kg and 4 μg/kg group showed superior controlled hypotension facilitation than 2 μg/kg fentanyl during FESS in terms of measurable haemodynamic endpoints and favourable operative conditions, surgeon's satisfaction and sparing of additional hypotensive agents.
Sections du résumé
BACKGROUND AND AIMS
OBJECTIVE
Fentanyl can facilitate controlled intraoperative hypotension by its sympatholytic effect in patients undergoing functional endoscopic sinus surgery (FESS). We investigated the effects of different doses of pre-induction fentanyl on controlled hypotension profile during FESS.
METHODS
METHODS
This prospective, randomised study included 120 patients randomly allocated to three groups (40 each) based on administration of pre-induction fentanyl; 2 μg/kg group, 3 μg/kg group and 4 μg/kg group. The primary objective was to assess effect on intraoperative heart rate and mean arterial pressure. Use of additional hypotensive agents, surgical field condition and surgeon satisfaction were also analysed.
RESULTS
RESULTS
Controlled hypotension was achieved adequately in all participants. Patients belonging to fentanyl 4 μg/kg group had significantly lower heart rate for the duration of controlled hypotension intraoperatively versus fentanyl 2 μg/kg group (
CONCLUSION
CONCLUSIONS
Pre-induction fentanyl 3 μg/kg and 4 μg/kg group showed superior controlled hypotension facilitation than 2 μg/kg fentanyl during FESS in terms of measurable haemodynamic endpoints and favourable operative conditions, surgeon's satisfaction and sparing of additional hypotensive agents.
Identifiants
pubmed: 31462812
doi: 10.4103/ija.IJA_866_18
pii: IJA-63-653
pmc: PMC6691639
doi:
Types de publication
Journal Article
Langues
eng
Pagination
653-659Déclaration de conflit d'intérêts
There are no conflicts of interest.
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