Single-dose pharmacokinetics of meropenem in porcine cancellous bone determined by microdialysis: An animal study.
Bone
Meropenem
Microdialysis
Penetration
Pharmacokinetics
Journal
Bone & joint research
ISSN: 2046-3758
Titre abrégé: Bone Joint Res
Pays: England
ID NLM: 101586057
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
30
8
2019
Statut:
epublish
Résumé
Meropenem may be an important drug in the treatment of open tibial fractures and chronic osteomyelitis. Therefore, the objective of this study was to describe meropenem pharmacokinetics in plasma, subcutaneous adipose tissue (SCT), and cancellous bone using microdialysis in a porcine model. Six female pigs were assigned to receive 1000 mg of meropenem intravenously over five minutes. Measurements of meropenem were obtained from plasma, SCT, and cancellous bone for eight hours thereafter. Microdialysis was applied for sampling in solid tissues. The meropenem concentrations were determined using ultra-high-performance liquid chromatography. The penetration of meropenem into cancellous bone, expressed as the ratio of plasma to cancellous bone area under the concentration-curve from zero to the last measured value, was incomplete and delayed. The time with concentration above the minimal inhibitory concentration (T The main finding of this study was short T
Identifiants
pubmed: 31463039
doi: 10.1302/2046-3758.87.BJR-2018-0308.R1
pii: 10.1302_2046-3758.87.BJR-2018-0308.R1
pmc: PMC6691366
doi:
Types de publication
Journal Article
Langues
eng
Pagination
313-322Références
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