Localization of the ultraviolet-sensor Opn5m and its effect on myopia-related gene expression in the late-embryonic chick eye.
Chicken
Egr1
Egr1, Early growth response 1
Fibroblasts
Gapdh, Glyceraldehyde-3-phosphate dehydrogenase
MAP kinase, mitogen-activated protein kinase
Mmp2
Mmp2, Matrix metalloproteinase 2
Opn5, Opsin 5
Opn5m, mammalian type Opn5
Opsin 5
Tgfb2, Transforming growth factor beta 2
Timp2, Tissue inhibitor of metalloproteinase 2
UV, ultraviolet
UV-A, ultraviolet-A
UV-Absorbing pigment
cAMP, cyclic adenosine monophosphate
qPCR, quantitative polymerase chain reaction
Journal
Biochemistry and biophysics reports
ISSN: 2405-5808
Titre abrégé: Biochem Biophys Rep
Pays: Netherlands
ID NLM: 101660999
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
15
02
2019
revised:
24
05
2019
accepted:
05
07
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
30
8
2019
Statut:
epublish
Résumé
Recent studies show that exposure to ultraviolet (UV) light suppresses ocular elongation, which causes myopia development. However, the specific mechanisms of this process have not been elucidated. A UV-sensor, Opsin 5 (Opn5) mRNA was shown to be present in extraretinal tissues. To test the possibility that UV-signals mediated by Opn5 would have a direct effect on the outer connective tissues of the eye, we first examined the expression patterns of a mammalian type Opn5 (Opn5m) in the late-embryonic chicken eye. Quantitative PCR showed
Identifiants
pubmed: 31463372
doi: 10.1016/j.bbrep.2019.100665
pii: S2405-5808(19)30020-2
pii: 100665
pmc: PMC6709407
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100665Commentaires et corrections
Type : ErratumIn
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