Acaricidal activity of plant-derived essential oil components against Psoroptes ovis in vitro and in vivo.
Acaricides
/ therapeutic use
Acyclic Monoterpenes
/ therapeutic use
Animals
Cattle
Cattle Diseases
/ drug therapy
Cymenes
/ therapeutic use
Eucalyptol
/ therapeutic use
Eugenol
/ therapeutic use
Female
Fumigation
Lethal Dose 50
Male
Mite Infestations
/ drug therapy
Oils, Volatile
/ therapeutic use
Plant Extracts
/ therapeutic use
Psoroptidae
/ drug effects
Acaricide
Cattle
Essential oils
In vitro
In vivo
Psoroptes ovis
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
29 Aug 2019
29 Aug 2019
Historique:
received:
10
06
2019
accepted:
01
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
6
2
2020
Statut:
epublish
Résumé
Treatment of Psoroptes ovis in cattle is limited to topical acaricides or systemic treatment with macrocyclic lactones. Treatment failure of macrocyclic lactones has been reported. The aim of this study was to evaluate a potential alternative treatment against P. ovis. The acaricidal activity against P. ovis of four plant-derived essential oil components, i.e. geraniol, eugenol, 1,8-cineol and carvacrol, was assessed in vitro and in vivo. In vitro contact, fumigation and residual bioassays were performed. In addition, 12 Belgium Blue cattle were artificially infested and treated topically once a week for three successive weeks with carvacrol in Tween-80 (treatment group) or with Tween-80 alone (control). The efficacy of carvacrol was determined by the reduction in lesion size and mite counts. Six additional animals were topically treated with carvacrol to assess local adverse reactions. Three components showed a concentration-dependent acaricidal activity in a contact assay, with LC Considering the strong acaricidal activity of carvacrol in vitro and in vivo and the mild and transient local side effects, carvacrol shows potential as an acaricidal agent in the treatment of P. ovis in cattle.
Sections du résumé
BACKGROUND
BACKGROUND
Treatment of Psoroptes ovis in cattle is limited to topical acaricides or systemic treatment with macrocyclic lactones. Treatment failure of macrocyclic lactones has been reported. The aim of this study was to evaluate a potential alternative treatment against P. ovis.
METHODS
METHODS
The acaricidal activity against P. ovis of four plant-derived essential oil components, i.e. geraniol, eugenol, 1,8-cineol and carvacrol, was assessed in vitro and in vivo. In vitro contact, fumigation and residual bioassays were performed. In addition, 12 Belgium Blue cattle were artificially infested and treated topically once a week for three successive weeks with carvacrol in Tween-80 (treatment group) or with Tween-80 alone (control). The efficacy of carvacrol was determined by the reduction in lesion size and mite counts. Six additional animals were topically treated with carvacrol to assess local adverse reactions.
RESULTS
RESULTS
Three components showed a concentration-dependent acaricidal activity in a contact assay, with LC
CONCLUSIONS
CONCLUSIONS
Considering the strong acaricidal activity of carvacrol in vitro and in vivo and the mild and transient local side effects, carvacrol shows potential as an acaricidal agent in the treatment of P. ovis in cattle.
Identifiants
pubmed: 31464634
doi: 10.1186/s13071-019-3654-x
pii: 10.1186/s13071-019-3654-x
pmc: PMC6714348
doi:
Substances chimiques
Acaricides
0
Acyclic Monoterpenes
0
Cymenes
0
Oils, Volatile
0
Plant Extracts
0
Eugenol
3T8H1794QW
carvacrol
9B1J4V995Q
geraniol
L837108USY
Eucalyptol
RV6J6604TK
Types de publication
Evaluation Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
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