A patient-reported questionnaire developed in a German early arthritis cohort to assess periodontitis in patients with rheumatoid arthritis.
Periodontitis
Rheumatoid arthritis
Self-reported questionnaire
Validation
Journal
Arthritis research & therapy
ISSN: 1478-6362
Titre abrégé: Arthritis Res Ther
Pays: England
ID NLM: 101154438
Informations de publication
Date de publication:
29 08 2019
29 08 2019
Historique:
received:
24
06
2019
accepted:
16
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
28
8
2020
Statut:
epublish
Résumé
The aim of this study was to develop a patient-reported questionnaire that is suitable to detect periodontitis (PD) in patients with rheumatoid arthritis (RA). A self-reported questionnaire containing 12 items potentially relevant to PD and dentists' semiquantitative assessment of PD (no/mild/moderate/severe) was obtained from 353 patients from an early arthritis cohort. Available radiographs (n = 253) and blinded assessment of 3 independent dentists were used for validation. By defining the dentists' assessment as the reference standard, relevant questionnaire items were identified with factor analysis methods. Receiver operator characteristic (ROC) plots were used to determine sensitivities and specificities to detect PD in varying severity. Ordinal regression models were used to determine the coefficients for the final score. Seventy percent had at least mild PD. The items from the questionnaire correlating best with the dentists' assessment were selected for a final 6-item score (number of teeth, gum pockets, receding gums, loose teeth, receding jaw bone and tooth extractions and age). For the detection of any/moderate/severe PD, the bias-corrected areas under the curve (AUC) were 0.81/0.83/0.90. Sensitivity to detect mild PD was 85% and specificity 57%. Very high specificity was achieved for the detection of severe PD with 99% at the cost of low sensitivity (28%). This patient-reported six-item score has moderate diagnostic properties to study PD in RA patients in epidemiological settings. We propose to use the score as a measure of periodontitis without applying cut-off values.
Sections du résumé
BACKGROUND
The aim of this study was to develop a patient-reported questionnaire that is suitable to detect periodontitis (PD) in patients with rheumatoid arthritis (RA).
METHODS
A self-reported questionnaire containing 12 items potentially relevant to PD and dentists' semiquantitative assessment of PD (no/mild/moderate/severe) was obtained from 353 patients from an early arthritis cohort. Available radiographs (n = 253) and blinded assessment of 3 independent dentists were used for validation. By defining the dentists' assessment as the reference standard, relevant questionnaire items were identified with factor analysis methods. Receiver operator characteristic (ROC) plots were used to determine sensitivities and specificities to detect PD in varying severity. Ordinal regression models were used to determine the coefficients for the final score.
RESULTS
Seventy percent had at least mild PD. The items from the questionnaire correlating best with the dentists' assessment were selected for a final 6-item score (number of teeth, gum pockets, receding gums, loose teeth, receding jaw bone and tooth extractions and age). For the detection of any/moderate/severe PD, the bias-corrected areas under the curve (AUC) were 0.81/0.83/0.90. Sensitivity to detect mild PD was 85% and specificity 57%. Very high specificity was achieved for the detection of severe PD with 99% at the cost of low sensitivity (28%).
CONCLUSIONS
This patient-reported six-item score has moderate diagnostic properties to study PD in RA patients in epidemiological settings. We propose to use the score as a measure of periodontitis without applying cut-off values.
Identifiants
pubmed: 31464650
doi: 10.1186/s13075-019-1982-z
pii: 10.1186/s13075-019-1982-z
pmc: PMC6716828
doi:
Types de publication
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
197Subventions
Organisme : Deutsche Rheuma-Liga Bundesverband e.V.
ID : NA
Pays : International
Organisme : Pfizer (D)
ID : NA
Pays : International
Références
Arthritis Res Ther. 2010;12(5):218
pubmed: 21062513
BMJ Open. 2017 Jan 31;7(1):e011916
pubmed: 28143836
J Periodontol. 2007 Jul;78(7 Suppl):1439-54
pubmed: 17610398
Int J Periodontics Restorative Dent. 2017 Jan/Feb;37(1):79-86
pubmed: 27977821
Rheumatol Int. 2015 Aug;35(8):1377-84
pubmed: 25663291
Rheumatology (Oxford). 2014 Mar;53(3):526-31
pubmed: 24273047
Front Immunol. 2016 Mar 02;7:80
pubmed: 26973655
J Periodontol. 2015 Jan;86(1):16-26
pubmed: 25269524
J Dent Res. 2005 Oct;84(10):881-90
pubmed: 16183785
Curr Rheumatol Rev. 2016;12(3):202-207
pubmed: 26496784
Eur J Oral Sci. 2005 Apr;113(2):135-40
pubmed: 15819819
J Periodontol. 2007 Jul;78(7 Suppl):1429-38
pubmed: 17608614
J Dent Res. 2013 May;92(5):399-408
pubmed: 23525531
J Periodontol. 2007 Jul;78(7 Suppl):1407-20
pubmed: 17608612
Behav Res Ther. 2003 Dec;41(12):1411-26
pubmed: 14583411
Korean J Intern Med. 2016 Sep;31(5):977-86
pubmed: 27017391