The cerebellum is involved in processing of predictions and prediction errors in a fear conditioning paradigm.
aversive conditioning
cerebellar hemisphere
emotions
extinction
fear
human
neuroscience
vermis
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
29 08 2019
29 08 2019
Historique:
received:
13
03
2019
accepted:
13
08
2019
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
8
2
2020
Statut:
epublish
Résumé
Prediction errors are thought to drive associative fear learning. Surprisingly little is known about the possible contribution of the cerebellum. To address this question, healthy participants underwent a differential fear conditioning paradigm during 7T magnetic resonance imaging. An event-related design allowed us to separate cerebellar fMRI signals related to the visual conditioned stimulus (CS) from signals related to the subsequent unconditioned stimulus (US; an aversive electric shock). We found significant activation of cerebellar lobules Crus I and VI bilaterally related to the CS+ compared to the CS-. Most importantly, significant activation of lobules Crus I and VI was also present during the unexpected omission of the US in unreinforced CS+ acquisition trials. This activation disappeared during extinction when US omission became expected. These findings provide evidence that the cerebellum has to be added to the neural network processing predictions and prediction errors in the emotional domain.
Identifiants
pubmed: 31464686
doi: 10.7554/eLife.46831
pii: 46831
pmc: PMC6715348
doi:
pii:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Deutsche Forschungsgemeinschaft
ID : 316803389 (SFB1280, project A11)
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : 316803389 (SFB1280, project A05)
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : 316803389 (SFB1280, project A09)
Pays : International
Informations de copyright
© 2019, Ernst et al.
Déclaration de conflit d'intérêts
TE, AB, MG, CR, UB, MS, SM, HQ, CM, DT No competing interests declared
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