New insights and perspectives on the genetics of obsessive-compulsive disorder.
Animals
Antidepressive Agents
/ metabolism
DNA Copy Number Variations
Disease Models, Animal
Endophenotypes
/ metabolism
Genetic Association Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Humans
Multifactorial Inheritance
Neuroimaging
Obsessive-Compulsive Disorder
/ genetics
Twins
/ genetics
Journal
Psychiatric genetics
ISSN: 1473-5873
Titre abrégé: Psychiatr Genet
Pays: England
ID NLM: 9106748
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
entrez:
30
8
2019
pubmed:
30
8
2019
medline:
27
2
2020
Statut:
ppublish
Résumé
Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessive-compulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genome-wide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction.
Identifiants
pubmed: 31464995
doi: 10.1097/YPG.0000000000000230
pii: 00041444-201910000-00003
doi:
Substances chimiques
Antidepressive Agents
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-151Références
Abdolhosseinzadeh S, Sina M, Ahmadiani A, Asadi S, Shams J. Genetic and pharmacogenetic study of glutamate transporter (SLC1A1) in Iranian patients with obsessive-compulsive disorder. J Clin Pharm Ther. 2019; 44:39–48
Aoyama K, Suh SW, Hamby AM, Liu J, Chan WY, Chen Y, Swanson RA. Neuronal glutathione deficiency and age-dependent neurodegeneration in the EAAC1 deficient mouse. Nat Neurosci. 2006; 9:119–126
Arnold PD, Rosenberg DR, Mundo E, Tharmalingam S, Kennedy JL, Richter MA. Association of a glutamate (NMDA) subunit receptor gene (GRIN2B) with obsessive-compulsive disorder: a preliminary study. Psychopharmacology (Berl). 2004; 174:530–538
Arnold PD, Macmaster FP, Richter MA, Hanna GL, Sicard T, Burroughs E, et al. Glutamate receptor gene (GRIN2B) associated with reduced anterior cingulate glutamatergic concentration in pediatric obsessive-compulsive disorder. Psychiatry Res. 2009a; 172:136–139
Arnold PD, Macmaster FP, Hanna GL, Richter MA, Sicard T, Burroughs E, et al. Glutamate system genes associated with ventral prefrontal and thalamic volume in pediatric obsessive-compulsive disorder. Brain Imag Behav. 2009b; 3:64–76
Atmaca M, Onalan E, Yildirim H, Yuce H, Koc M, Korkmaz S. The association of myelin oligodendrocyte glycoprotein gene and white matter volume in obsessive-compulsive disorder. J Affect Disord. 2010; 124:309–313
Atmaca M, Onalan E, Yildirim H, Yuce H, Koc M, Korkmaz S, Mermi O. Serotonin transporter gene polymorphism implicates reduced orbito-frontal cortex in obsessive-compulsive disorder. J Anxiety Disord. 2011; 25:680–685
Bandelow B, Baldwin D, Abelli M, Altamura C, Dell’Osso B, Domschke K, et al. Biological markers for anxiety disorders, OCD and PTSD - a consensus statement. Part I: neuroimaging and genetics. World J Biol Psychiatry. 2016; 17:321–365
Bearden CE, Thompson PM. Emerging global initiatives in neurogenetics: the enhancing neuroimaging genetics through meta-analysis (ENIGMA) consortium. Neuron. 2017; 94:232–236
Berman AE, Chan WY, Brennan AM, Reyes RC, Adler BL, Suh SW, et al. N-acetylcysteine prevents loss of dopaminergic neurons in the EAAC1-/- mouse. Ann Neurol. 2011; 69:509–520
Bienvenu OJ, Wang Y, Shugart YY, Welch JM, Grados MA, Fyer AJ, et al. Sapap3 and pathological grooming in humans: results from the OCD collaborative genetics study. Am J Med Genet B Neuropsychiatr Genet. 2009; 150B:710–720
Boardman L, van der Merwe L, Lochner C, Kinnear CJ, Seedat S, Stein DJ, et al. Investigating SAPAP3 variants in the etiology of obsessive-compulsive disorder and trichotillomania in the south african white population. Compr Psychiatry. 2011; 52:181–187
Bogdan R, Salmeron BJ, Carey CE, Agrawal A, Calhoun V D, Garavan H, et al. Imaging genetics and genomics in psychiatry: a critical review of progress and potential. Biol Psychiatry. 2017; 82:165–175
Bradbury C, Cassin SE, Rector NA. Obsessive beliefs and neurocognitive flexibility in obsessive-compulsive disorder. Psychiatry Res. 2011; 187:160–165
Brainstorm C, Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, et al. Analysis of shared heritability in common disorders of the brain. Science. 2018; 360:pii: eaap8757
Brander G, Pérez-Vigil A, Larsson H, Mataix-Cols D. Systematic review of environmental risk factors for obsessive-compulsive disorder: a proposed roadmap from association to causation. Neurosci Biobehav Rev. 2016a; 65:36–62
Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al. Association of perinatal risk factors with obsessive-compulsive disorder: a population-based birth cohort, sibling control study. JAMA Psychiatry. 2016b; 73:1135–1144
Brander G, Rydell M, Kuja-Halkola R, Fernández de la Cruz L, Lichtenstein P, Serlachius E, et al. Perinatal risk factors in tourette’s and chronic tic disorders: a total population sibling comparison study. Mol Psychiatry. 2018; 23:1189–1197
Brandl EJ, Tiwari AK, Zhou X, Deluce J, Kennedy JL, Müller DJ, Richter MA. Influence of CYP2D6 and CYP2C19 gene variants on antidepressant response in obsessive-compulsive disorder. Pharmacogenomics J. 2014; 14:176–181
Brem S, Grünblatt E, Drechsler R, Riederer P, Walitza S. The neurobiological link between OCD and ADHD. Atten Defic Hyperact Disord. 2014; 6:175–202
Browne HA, Gair SL, Scharf JM, Grice DE. Genetics of obsessive-compulsive disorder and related disorders. Psychiatr Clin North Am. 2014; 37:319–335
Cappi C, Hounie AG, Mariani DB, Diniz JB, Silva AR, Reis VN, et al. An inherited small microdeletion at 15q13.3 in a patient with early-onset obsessive-compulsive disorder. Plos One. 2014; 9:e110198
Cappi C, Diniz JB, Requena GL, Lourenço T, Lisboa BC, Batistuzzo MC, et al. Epigenetic evidence for involvement of the oxytocin receptor gene in obsessive-compulsive disorder. BMC Neurosci. 2016; 17:79
Chamberlain SR, Blackwell AD, Fineberg NA, Robbins TW, Sahakian BJ. The neuropsychology of obsessive compulsive disorder: the importance of failures in cognitive and behavioural inhibition as candidate endophenotypic markers. Neurosci Biobehav Rev. 2005; 29:399–419
Chamberlain SR, Fineberg NA, Blackwell AD, Robbins TW, Sahakian BJ. Motor inhibition and cognitive flexibility in obsessive-compulsive disorder and trichotillomania. Am J Psychiatry. 2006; 163:1282–1284
Corregiari FM, Bernik M, Cordeiro Q, Vallada H. Endophenotypes and serotonergic polymorphisms associated with treatment response in obsessive-compulsive disorder. Clinics (Sao Paulo). 2012; 67:335–340
Costas J, Carrera N, Alonso P, Gurriarán X, Segalàs C, Real E, et al. Exon-focused genome-wide association study of obsessive-compulsive disorder and shared polygenic risk with schizophrenia. Transl Psychiatry. 2016; 6:e768
da Rocha FF, Malloy-Diniz L, Lage NV, Corrêa H. The relationship between the met allele of the BDNF val66met polymorphism and impairments in decision making under ambiguity in patients with obsessive-compulsive disorder. Genes Brain Behav. 2011; 10:523–529
Davis LK, Yu D, Keenan CL, Gamazon ER, Konkashbaev AI, Derks EM, et al. Partitioning the heritability of tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture. Plos Genet. 2013; 9:e1003864
de Salles Andrade JB, Giori IG, Melo-Felippe FB, Vieira-Fonseca T, Fontenelle LF, Kohlrausch FB. Glutamate transporter gene polymorphisms and obsessive-compulsive disorder: a case-control association study. J Clin Neurosci. 2019; 62:53–59
Delorme R, Moreno-De-Luca D, Gennetier A, Maier W, Chaste P, Mossner R, et al. Search for copy number variants in chromosomes 15q11-q13 and 22q11.2 in obsessive compulsive disorder. BMC Med Genet. 2010; 11:100
den Braber A, Zilhão NR, Fedko IO, Hottenga JJ, Pool R, Smit DJ, et al. Obsessive-compulsive symptoms in a large population-based twin-family sample are predicted by clinically based polygenic scores and by genome-wide snps. Transl Psychiatry. 2016; 6:e731
Di Nocera F, Colazingari S, Trabalza A, Mamazza L, Bevilacqua A. Association of TPH2 and dopamine receptor gene polymorphisms with obsessive-compulsive symptoms and perfectionism in healthy subjects. Psychiatry Res. 2014; 220:1172–1173
Dickel DE, Veenstra-VanderWeele J, Cox NJ, Wu X, Fischer DJ, Van Etten-Lee M, et al. Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder. Arch Gen Psychiatry. 2006; 63:778–785
Elliott LS, Henderson JC, Neradilek MB, Moyer NA, Ashcraft KC, Thirumaran RK. Clinical impact of pharmacogenetic profiling with a clinical decision support tool in polypharmacy home health patients: a prospective pilot randomized controlled trial. Plos One. 2017; 12:e0170905
Fernandez TV, Sanders SJ, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman DO, et al. Rare copy number variants in tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biol Psychiatry. 2012; 71:392–402
Foa EB, Liebowitz MR, Kozak MJ, Davies S, Campeas R, Franklin ME, et al. Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. Am J Psychiatry. 2005; 162:151–161
Fullana MA, Mataix-Cols D, Caspi A, Harrington H, Grisham JR, Moffitt TE, Poulton R. Obsessions and compulsions in the community: prevalence, interference, help-seeking, developmental stability, and co-occurring psychiatric conditions. Am J Psychiatry. 2009; 166:329–336
Gassó P, Ortiz AE, Mas S, Morer A, Calvo A, Bargalló N, et al. Association between genetic variants related to glutamatergic, dopaminergic and neurodevelopment pathways and white matter microstructure in child and adolescent patients with obsessive-compulsive disorder. J Affect Disord. 2015; 186:284–292
Gazzellone MJ, Zarrei M, Burton CL, Walker S, Uddin M, Shaheen SM, et al. Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation. J Neurodev Disord. 2016; 8:36
Glahn DC, Knowles EE, McKay DR, Sprooten E, Raventós H, Blangero J, et al. Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics. Am J Med Genet B Neuropsychiatr Genet. 2014; 165B:122–130
Gottesman II, Gould TD. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry. 2003; 160:636–645
Greer JM, Capecchi MR. Hoxb8 is required for normal grooming behavior in mice. Neuron. 2002; 33:23–34
Grünblatt E, Hauser TU, Walitza S. Imaging genetics in obsessive-compulsive disorder: linking genetic variations to alterations in neuroimaging. Prog Neurobiol. 2014; 121:114–124
Grünblatt E, Oneda B, Ekici AB, Ball J, Geissler J, Uebe S, et al. High resolution chromosomal microarray analysis in paediatric obsessive-compulsive disorder. BMC Med Genomics. 2017; 10:68
Grünblatt E, Marinova Z, Roth A, Gardini E, Ball J, Geissler J, et al. Combining genetic and epigenetic parameters of the serotonin transporter gene in obsessive-compulsive disorder. J Psychiatr Res. 2018; 96:209–217
Guo Y, Su L, Zhang J, Lei J, Deng X, Xu H, et al. Analysis of the BTBD9 and HTR2C variants in Chinese Han patients with Tourette syndrome. Psychiatr Genet. 2012; 22:300–303
Guo W, Samuels JF, Wang Y, Cao H, Ritter M, Nestadt PS, et al. Polygenic risk score and heritability estimates reveals a genetic relationship between ASD and OCD. Eur Neuropsychopharmacol. 2017; 27:657–666
Hesse S, Stengler K, Regenthal R, Patt M, Becker GA, Franke A, et al. The serotonin transporter availability in untreated early-onset and late-onset patients with obsessive-compulsive disorder. Int J Neuropsychopharmacol. 2011; 14:606–617
Hirschtritt ME, Bloch MH, Mathews CA. Obsessive-compulsive disorder: advances in diagnosis and treatment. JAMA. 2017; 317:1358–1367
Hoekstra PJ, Dietrich A, Edwards MJ, Elamin I, Martino D. Environmental factors in Tourette syndrome. Neurosci Biobehav Rev. 2013; 37:1040–1049
Honda S, Nakao T, Mitsuyasu H, Okada K, Gotoh L, Tomita M, et al. A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients. Ann Gen Psychiatry. 2017; 16:2
International Obsessive Compulsive Disorder Foundation Genetics C, Studies OCDCGA; International Obsessive Compulsive Disorder Foundation Genetics C, Studies OCDCGA. Revealing the complex genetic architecture of obsessive-compulsive disorder using meta-analysis. Mol Psychiatr. 2018; 23:1181–1188
Katzman MA, Bleau P, Blier P, Chokka P, Kjernisted K, Van Ameringen M, et al; Canadian Anxiety Guidelines Initiative Group on behalf of the Anxiety Disorders Association of Canada/Association Canadienne des troubles anxieux and McGill University. Canadian clinical practice guidelines for the management of anxiety, posttraumatic stress and obsessive-compulsive disorders. BMC Psychiatry. 2014; 14Suppl 1S1
Kim HW, Kang JI, Hwang EH, Kim SJ. Association between glutamate transporter gene polymorphisms and obsessive-compulsive disorder/trait empathy in a Korean population. Plos One. 2018; 13:e0190593
Koo MS, Kim EJ, Roh D, Kim CH. Role of dopamine in the pathophysiology and treatment of obsessive-compulsive disorder. Expert Rev Neurother. 2010; 10:275–290
Koran LM, Hanna GL, Hollander E, Nestadt G, Simpson HB; American Psychiatric Association. Practice guideline for the treatment of patients with obsessive-compulsive disorder. Am J Psychiatry. 2007; 164:5–53
Lisoway AJ, Zai G, Tiwari AK, Zai CC, Wigg K, Goncalves V, et al. Pharmacogenetic evaluation of a DISP1 gene variant in antidepressant treatment of obsessive-compulsive disorder. Hum Psychopharmacol. 2018; 33:e2659
Liu S, Yin Y, Wang Z, Zhang X, Ma X. Association study between MAO-A gene promoter VNTR polymorphisms and obsessive-compulsive disorder. J Anxiety Disord. 2013; 27:435–437
Mas S, Pagerols M, Gassó P, Ortiz A, Rodriguez N, Morer A, et al. Role of GAD2 and HTR1B genes in early-onset obsessive-compulsive disorder: results from transmission disequilibrium study. Genes Brain Behav. 2014; 13:409–417
Mas S, Gassó P, Morer A, Calvo A, Bargalló N, Lafuente A, Lázaro L. Integrating genetic, neuropsychological and neuroimaging data to model early-onset obsessive compulsive disorder severity. Plos One. 2016; 11:e0153846
Mattheisen M, Samuels JF, Wang Y, Greenberg BD, Fyer AJ, McCracken JT, et al. Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS. Mol Psychiatry. 2015; 20:337–344
Mattingsdal M, Brown AA, Djurovic S, Sønderby IE, Server A, Melle I, et al. Pathway analysis of genetic markers associated with a functional MRI faces paradigm implicates polymorphisms in calcium responsive pathways. Neuroimage. 2013; 70:143–149
McDougle CJ, Goodman WK, Leckman JF, Price LH. The psychopharmacology of obsessive compulsive disorder. Implications for treatment and pathogenesis. Psychiatr Clin North Am. 1993; 16:749–766
McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, et al. Copy number variation in obsessive-compulsive disorder and tourette syndrome: a cross-disorder study. J Am Acad Child Adolesc Psychiatry. 2014; 53:910–919
McGregor NW, Hemmings SMJ, Erdman L, Calmarza-Font I, Stein DJ, Lochner C. Modification of the association between early adversity and obsessive-compulsive disorder by polymorphisms in the MAOA, MAOB and COMT genes. Psychiatry Res. 2016; 246:527–532
Meda SA, Narayanan B, Liu J, Perrone-Bizzozero NI, Stevens MC, Calhoun VD, et al. A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer’s disease in the ADNI cohort. Neuroimage. 2012; 60:1608–1621
Medland SE, Jahanshad N, Neale BM, Thompson PM. Whole-genome analyses of whole-brain data: working within an expanded search space. Nat Neurosci. 2014; 17:791–800
Melo-Felippe FB, de Salles Andrade JB, Giori IG, Vieira-Fonseca T, Fontenelle LF, Kohlrausch FB. Catechol-O-methyltransferase gene polymorphisms in specific obsessive-compulsive disorder patients’ subgroups. J Mol Neurosci. 2016; 58:129–136
Miguita K, Cordeiro Q, Shavitt RG, Miguel EC, Vallada H. Association study between genetic monoaminergic polymorphisms and OCD response to clomipramine treatment. Arq Neuropsiquiatr. 2011; 69:283–287
Monteiro P, Feng G. Learning from animal models of obsessive-compulsive disorder. Biol Psychiatry. 2016; 79:7–16
Müller DJ, Brandl EJ, Hwang R, Tiwari AK, Sturgess JE, Zai CC, et al. The amplichip® CYP450 test and response to treatment in schizophrenia and obsessive compulsive disorder: a pilot study and focus on cases with abnormal CYP2D6 drug metabolism. Genet Test Mol Biomarkers. 2012; 16:897–903
Murphy DL, Moya PR, Fox MA, Rubenstein LM, Wendland JR, Timpano KR. Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. Philos Trans R Soc Lond B Biol Sci. 2013; 368:20120435
Nag A, Bochukova EG, Kremeyer B, Campbell DD, Muller H, Valencia-Duarte AV, et al; Tourette Syndrome Association International Consortium for Genetics. CNV analysis in Tourette syndrome implicates large genomic rearrangements in COL8A1 and NRXN1. Plos One. 2013; 8:e59061
Nestadt G, Samuels J, Riddle M, Bienvenu OJ III, Liang KY, LaBuda M, et al. A family study of obsessive-compulsive disorder. Arch Gen Psychiatry. 2000; 57:358–363
Nissen JB, Hansen CS, Starnawska A, Mattheisen M, Børglum AD, Buttenschøn HN, Hollegaard M. DNA methylation at the neonatal state and at the time of diagnosis: preliminary support for an association with the estrogen receptor 1, gamma-aminobutyric acid B receptor 1, and myelin oligodendrocyte glycoprotein in female adolescent patients with OCD. Front Psychiatry. 2016; 7:35
Noh HJ, Tang R, Flannick J, O’Dushlaine C, Swofford R, Howrigan D, et al. Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder. Nat Commun. 2017; 8:774
Nymberg C, Jia T, Ruggeri B, Schumann G. Analytical strategies for large imaging genetic datasets: experiences from the IMAGEN study. Ann N Y Acad Sci. 2013; 1282:92–106
Ortiz AE, Gassó P, Mas S, Falcon C, Bargalló N, Lafuente A, Lázaro L. Association between genetic variants of serotonergic and glutamatergic pathways and the concentration of neurometabolites of the anterior cingulate cortex in paediatric patients with obsessive-compulsive disorder. World J Biol Psychiatry. 2016; 17:394–404
Pauls DL. The genetics of obsessive-compulsive disorder: a review. Dialogues Clin Neurosci. 2010; 12:149–163
Pauls DL, Abramovitch A, Rauch SL, Geller DA. Obsessive-compulsive disorder: an integrative genetic and neurobiological perspective. Nat Rev Neurosci. 2014; 15:410–424
Qin H, Samuels JF, Wang Y, Zhu Y, Grados MA, Riddle MA, et al. Whole-genome association analysis of treatment response in obsessive-compulsive disorder. Mol Psychiatry. 2016; 21:270–276
Ritter ML, Guo W, Samuels JF, Wang Y, Nestadt PS, Krasnow J, et al. Genome Wide Association Study (GWAS) between Attention Deficit Hyperactivity Disorder (ADHD) and Obsessive Compulsive Disorder (OCD). Front Mol Neurosci. 2017; 10:83
Ruscio AM, Stein DJ, Chiu WT, Kessler RC. The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication. Mol Psychiatry. 2010; 15:53–63
Sampaio AS, Hounie AG, Petribú K, Cappi C, Morais I, Vallada H, et al. COMT and MAO-A polymorphisms and obsessive-compulsive disorder: a family-based association study. Plos One. 2015; 10:e0119592
Saxena S, Rauch SL. Functional neuroimaging and the neuroanatomy of obsessive-compulsive disorder. Psychiatr Clin North Am. 2000; 23:563–586
Scherk H, Backens M, Schneider-Axmann T, Kraft S, Kemmer C, Usher J, et al. Dopamine transporter genotype influences N-acetyl-aspartate in the left putamen. World J Biol Psychiatry. 2009; 10:524–530
Scimemi A, Tian H, Diamond JS. Neuronal transporters regulate glutamate clearance, NMDA receptor activation, and synaptic plasticity in the hippocampus. J Neurosci. 2009; 29:14581–14595
Shmelkov SV, Hormigo A, Jing D, Proenca CC, Bath KG, Milde T, et al. Slitrk5 deficiency impairs corticostriatal circuitry and leads to obsessive-compulsive-like behaviors in mice. Nat Med. 2010; 16:598–602, 1p following 602
Sinopoli VM, Burton CL, Kronenberg S, Arnold PD. A review of the role of serotonin system genes in obsessive-compulsive disorder. Neurosci Biobehav Rev. 2017; 80:372–381
Soomro GM, Altman D, Rajagopal S, Oakley-Browne M. Selective serotonin re-uptake inhibitors (SSRIs) versus placebo for obsessive compulsive disorder (OCD). Cochrane Database Syst Rev. 2008; 23:CD001765
Stewart SE, Fagerness JA, Platko J, Smoller JW, Scharf JM, Illmann C, et al. Association of the SLC1A1 glutamate transporter gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2007a; 144B:1027–1033
Stewart SE, Platko J, Fagerness J, Birns J, Jenike E, Smoller JW, et al. A genetic family-based association study of OLIG2 in obsessive-compulsive disorder. Arch Gen Psychiatry. 2007b; 64:209–214
Stewart SE, Mayerfeld C, Arnold PD, Crane JR, O’Dushlaine C, Fagerness JA, et al. Meta-analysis of association between obsessive-compulsive disorder and the 3’ region of neuronal glutamate transporter gene SLC1A1. Am J Med Genet B Neuropsychiatr Genet. 2013a; 162B:367–379
Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, et al; North American Brain Expression Consortium; UK Brain Expression Database. Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry. 2013b; 18:788–798
Taj MJRJ, Ganesh S, Shukla T, Deolankar S, Nadella RK, Sen S, et al. BDNF gene and obsessive compulsive disorder risk, symptom dimensions and treatment response. Asian J Psychiatr. 2018; 38:65–69
Taylor S. Molecular genetics of obsessive-compulsive disorder: a comprehensive meta-analysis of genetic association studies. Mol Psychiatry. 2013; 18:799–805
Taylor S. Disorder-specific genetic factors in obsessive-compulsive disorder: a comprehensive meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2016; 171B:325–332
Thompson PM, Stein JL, Medland SE, Hibar DP, Vasquez AA, Renteria ME, et al. The ENIGMA consortium: large-scale collaborative analyses of neuroimaging and genetic data. Brain Imaging Behav. 2014; 8:153–182
Ting JT, Feng G. Neurobiology of obsessive-compulsive disorder: insights into neural circuitry dysfunction through mouse genetics. Curr Opin Neurobiol. 2011; 21:842–848
Tükel R, Gürvit H, Ozata B, Oztürk N, Ertekin BA, Ertekin E, et al. Brain-derived neurotrophic factor gene val66met polymorphism and cognitive function in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2012; 159B:850–858
Tükel R, Gürvit H, Öztürk N, Özata B, Ertekin BA, Ertekin E, et al. COMT val158met polymorphism and executive functions in obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci. 2013; 25:214–221
Umehara H, Numata S, Tajima A, Kinoshita M, Nakaaki S, Imoto I, et al. No association between the COMT val158met polymorphism and the long-term clinical response in obsessive-compulsive disorder in the Japanese population. Hum Psychopharmacol. 2015; 30:372–376
van de Vondervoort I, Poelmans G, Aschrafi A, Pauls DL, Buitelaar JK, Glennon JC, et al. An integrated molecular landscape implicates the regulation of dendritic spine formation through insulin-related signalling in obsessive-compulsive disorder. J Psychiatry Neurosci. 2016; 41:280–285
van Grootheest DS, Cath DC, Beekman AT, Boomsma DI. Twin studies on obsessive-compulsive disorder: a review. Twin Res Hum Genet. 2005; 8:450–458
Van Nieuwerburgh FC, Denys DA, Westenberg HG, Deforce DL. Response to serotonin reuptake inhibitors in OCD is not influenced by common CYP2D6 polymorphisms. Int J Psychiatry Clin Pract. 2009; 13:345–348
Viswanath B, Taj MJR, Purushottam M, Kandavel T, Shetty PH, Reddy YC, et al. No association between DRD4 gene and SRI treatment response in obsessive compulsive disorder: need for a novel approach. Asian J Psychiatr. 2013; 6:347–348
Vulink NC, Westenberg HG, van Nieuwerburgh F, Deforce D, Fluitman SB, Meinardi JS, Denys D. Catechol-O-methyltranferase gene expression is associated with response to citalopram in obsessive-compulsive disorder. Int J Psychiatry Clin Pract. 2012; 16:277–283
Walitza S, Wewetzer C, Gerlach M, Klampfl K, Geller F, Barth N, et al. Transmission disequilibrium studies in children and adolescents with obsessive-compulsive disorders pertaining to polymorphisms of genes of the serotonergic pathway. J Neural Transm (Vienna). 2004; 111:817–825
Walitza S, Bové DS, Romanos M, Renner T, Held L, Simons M, et al. Pilot study on HTR2A promoter polymorphism, -1438G/A (rs6311) and a nearby copy number variation showed association with onset and severity in early onset obsessive-compulsive disorder. J Neural Transm (Vienna). 2012; 119:507–515
Walitza S, Marinova Z, Grünblatt E, Lazic SE, Remschmidt H, Vloet TD, Wendland JR. Trio study and meta-analysis support the association of genetic variation at the serotonin transporter with early-onset obsessive-compulsive disorder. Neurosci Lett. 2014; 580:100–103
Welch JM, Lu J, Rodriguiz RM, Trotta NC, Peca J, Ding JD, et al. Cortico-striatal synaptic defects and OCD-like behaviours in sapap3-mutant mice. Nature. 2007; 448:894–900
Wolf C, Mohr H, Schneider-Axmann T, Reif A, Wobrock T, Scherk H, et al. CACNA1C genotype explains interindividual differences in amygdala volume among patients with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2014; 264:93–102
Wu K, Hanna GL, Rosenberg DR, Arnold PD. The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. Pharmacol Biochem Behav. 2012; 100:726–735
Wu K, Hanna GL, Easter P, Kennedy JL, Rosenberg DR, Arnold PD. Glutamate system genes and brain volume alterations in pediatric obsessive-compulsive disorder: a preliminary study. Psychiatr Res. 2013; 211:214–220
Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, et al. Cross-disorder genome-wide analyses suggest a complex genetic relationship between Tourette’s syndrome and OCD. Am J Psychiatry. 2015; 172:82–93
Yue W, Cheng W, Liu Z, Tang Y, Lu T, Zhang D, et al. Genome-wide DNA methylation analysis in obsessive-compulsive disorder patients. Sci Rep. 2016; 6:31333
Zai G, Bezchlibnyk YB, Richter MA, Arnold P, Burroughs E, Barr CL, Kennedy JL. Myelin oligodendrocyte glycoprotein (MOG) gene is associated with obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2004; 129B:64–68
Zai G, Brandl EJ, Müller DJ, Richter MA, Kennedy JL. Pharmacogenetics of antidepressant treatment in obsessive-compulsive disorder: an update and implications for clinicians. Pharmacogenomics. 2014; 15:1147–1157
Zai G, Zai CC, Arnold PD, Freeman N, Burroughs E, Kennedy JL, Richter MA. Meta-analysis and association of brain-derived neurotrophic factor (BDNF) gene with obsessive-compulsive disorder. Psychiatr Genet. 2015; 25:95–96
Zhang L, Liu X, Li T, Yang Y, Hu X, Collier D. Molecular pharmacogenetic studies of drug responses to obsessive-compulsive disorder and six functional genes. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004; 21:479–481
Zhang K, Cao L, Zhu W, Wang G, Wang Q, Hu H, et al. Association between the efficacy of fluoxetine treatment in obsessive-compulsive disorder patients and SLC1A1 in a Han Chinese population. Psychiatry research. 2015a; 229:631–632
Zhang X, Liu J, Guo Y, Jiang W, Yu J. Association study between oligodendrocyte transcription factor 2 gene and obsessive-compulsive disorder in a Chinese Han population. Depress Anxiety. 2015b; 32:720–727
Zilhão NR, Smit DJ, Boomsma DI, Cath DC. Cross-disorder genetic analysis of tic disorders, obsessive-compulsive, and hoarding symptoms. Front Psychiatry. 2016; 7:120
Züchner S, Wendland JR, Ashley-Koch AE, Collins AL, Tran-Viet KN, Quinn K, et al. Multiple rare SAPAP3 missense variants in trichotillomania and OCD. Mol Psychiatry. 2009; 14:6–9