Enrichment of HDL proteome and phospholipidome from human serum via IMAC/MOAC affinity.
HDL
HDL-omics work flow
human serum
intact apoproteins
lipoprotein extraction
phospholipids
Journal
Biomedical chromatography : BMC
ISSN: 1099-0801
Titre abrégé: Biomed Chromatogr
Pays: England
ID NLM: 8610241
Informations de publication
Date de publication:
Jan 2020
Jan 2020
Historique:
received:
13
07
2019
revised:
17
08
2019
accepted:
23
08
2019
pubmed:
30
8
2019
medline:
23
1
2020
entrez:
30
8
2019
Statut:
ppublish
Résumé
High-density lipoproteins (HDLs) have anti-inflammatory and antioxidant properties and are potentially cardio-protective. Defective HDL function is caused by alterations in both the proteome and lipidome of HDL particles. As potential biomarkers, the development of analytical methods is necessary for the enrichment of HDLs. Therefore, a method for selective enrichment of HDLs using immobilized metal ion affinity chromatography (IMAC) and metal oxide affinity chromatography (MOAC) is presented. SPE-based isolation of HDLs from whole serum is adopted as an alternative to traditional ultracentrifugation methods followed by SDS-PAGE. The enrichment mechanism relies on isoelectric points of lipoproteins and metal oxide. Negatively charged lipoprotein particles interact with positively charged metal oxides and IMAC affinity, which acts as a cation. Identified proteins from HDL through MALDI-MS analysis are apo AI, AII, AIV, CI, CIII, E, J, M, H, serum amyloid A and other nonapoproteins that are part of HDL particles and perform cellular functions. This serum-based proteomics approach gives insight into the functional role of HDL. HDL-associated phospholipids have also been analyzed by LDI-MS. Results suggest that the adopted analytical strategy is a feasible idea to extract lipoproteins from serum. A comparative study of healthy and diseased samples using this approach will provide valuable information in future.
Substances chimiques
Lipoproteins, HDL
0
Phospholipids
0
Proteome
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e4693Subventions
Organisme : Higher Education Commission, Pakistan
Informations de copyright
© 2019 John Wiley & Sons, Ltd.
Références
Adorni, M. P., Zimetti, F., Cangiano, B., Vezzoli, V., Bernini, F., Caruso, D., … Ruscica, M. (2019). High density lipoprotein function is reduced in patients affected by genetic or idiopathic hypogonadism. The Journal of Clinical Endocrinology and Metabolism., 104, 3097-3107. https://doi.org/10.1210/jc.2018-02027
Alwaili, K., Bailey, D., Awan, Z., Bailey, S. D., Ruel, I., Hafiane, A., … Genest, J. (2012). The HDL proteome in acute coronary syndromes shifts to an inflammatory profile. Biochimica et Biophysica Acta-Molecular and Cell Biology of Lipids, 1821(3), 405-415.
Böing, A. N., Van Der Pol, E., Grootemaat, A. E., Coumans, F. A., Sturk, A., & Nieuwland, R. (2014). Single-step isolation of extracellular vesicles by size-exclusion chromatography. Journal of Extracellular Vesicles, 3(1), 23430. https://doi.org/10.3402/jev.v3.23430
Chen, D., Hu, Y.-N., Hussain, D., Zhu, G.-T., Huang, Y.-Q., & Feng, Y.-Q. (2016). Electrospun fibrous thin film microextraction coupled with desorption corona beam ionization-mass spectrometry for rapid analysis of antidepressants in human plasma. Talanta, 152, 188-195. https://doi.org/10.1016/j.talanta.2016.02.003
Collaboration ERF (2009). Major lipids, apolipoproteins, and risk of vascular disease. JAMA: The Journal of the American Medical Association, 302(18), 1993.
Collier, T. S., Jin, Z., Topbas, C., & Bystrom, C. (2018). Rapid affinity enrichment of human apolipoprotein A-I associated lipoproteins for proteome analysis. Journal of Proteome Research, 17(3), 1183-1193. https://doi.org/10.1021/acs.jproteome.7b00816
Dashti, M., Kulik, W., Hoek, F., Veerman, E. C., Peppelenbosch, M. P., & Rezaee, F. (2011). A phospholipidomic analysis of all defined human plasma lipoproteins. Scientific Reports, 1, 139. https://doi.org/10.1038/srep00139, http://www.nature.com/articles/srep00139#supplementary-information
Gordon, S. M., Deng, J., Lu, L. J., & Davidson, W. S. (2010). Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration chromatography. Journal of Proteome Research, 9(10), 5239-5249. https://doi.org/10.1021/pr100520x
Holzer, M., Kern, S., Birner-Grünberger, R., Curcic, S., Heinemann, A., & Marsche, G. (2016). Refined purification strategy for reliable proteomic profiling of HDL2/3: Impact on proteomic complexity. Scientific Reports, 6, 38533. https://doi.org/10.1038/srep38533, http://www.nature.com/articles/srep38533#supplementary-information
Honda, K., & Srivastava, S. (2016). Potential usefulness of apolipoprotein A2 isoforms for screening and risk stratification of pancreatic cancer. Biomarkers in Medicine, 10(11), 1197-1207. https://doi.org/10.2217/bmm-2016-0209
Hussain, D., Musharraf, S. G., & Najam-ul-Haq, M. (2016). Development of diamond-lanthanide metal oxide affinity composites for the selective capture of endogenous serum phosphopeptides. Analytical and Bioanalytical Chemistry, 408(6), 1633-1641. https://doi.org/10.1007/s00216-015-9272-3
Hussain, D., Najam-ul-Haq, M., Jabeen, F., Ashiq, M. N., Athar, M., Rainer, M., … Bonn, G. K. (2013). Functionalized diamond nanopowder for phosphopeptides enrichment from complex biological fluids. Analytica Chimica Acta, 775, 75-84. https://doi.org/10.1016/j.aca.2013.03.007
Hussain, D., Najam-ul-Haq, M., Majeed, S., Musharraf, S. G., Lu, Q., He, X., & Feng, Y.-Q. (2019). Facile liquid-phase deposition synthesis of titania-coated magnetic sporopollenin for the selective capture of phosphopeptides. Analytical and Bioanalytical Chemistry, 411(15), 3373-3382. https://doi.org/10.1007/s00216-019-01811-4
Huuskonen, J., Olkkonen, V. M., Jauhiainen, M., & Ehnholm, C. (2001). The impact of phospholipid transfer protein (PLTP) on HDL metabolism. Atherosclerosis, 155(2), 269-281. https://doi.org/10.1016/S0021-9150(01)00447-6
Jabeen, F., Hussain, D., Fatima, B., Musharraf, S. G., Huck, C. W., Bonn, G. K., & Najam-ul-Haq, M. (2012). Silica-lanthanum oxide: Pioneer composite of rare-earth metal oxide in selective phosphopeptides enrichment. Analytical Chemistry, 84(23), 10180-10185. https://doi.org/10.1021/ac3023197
Jabeen, F., Najam-ul-Haq, M., Rainer, M., Yk, G., Huck, C. W., & Bonn, G. K. (2015). Newly fabricated magnetic lanthanide oxides core-shell nanoparticles in phosphoproteomics. Analytical Chemistry, 87(9), 4726-4732. https://doi.org/10.1021/ac504818s
Javeed, R., Jabeen, F., Saeed, H., & Najam-ul-Haq, M. (2015). Advance workflow in lipoproteomics via polymeric ion exchanger. Analytical Chemistry, 87(6), 3505-3512. https://doi.org/10.1021/acs.analchem.5b00058
Karlsson, H., Lindqvist, H., Tagesson, C., & Lindahl, M. (2006). Characterization of apolipoprotein M isoforms in low-density lipoprotein. Journal of Proteome Research, 5(10), 2685-2690. https://doi.org/10.1021/pr060180x
Kawakami, A., Tanaka, A., Nakano, T., Saniabadi, A., & Numano, F. (2001). Stimulation of arterial smooth muscle cell proliferation by remnant lipoprotein particles isolated by immuno-affinity chromatography with anti-apo A-I and anti-apo B-100. Hormone and Metabolic Research, 33(02), 67-72. https://doi.org/10.1055/s-2001-12397
Kontush, A., & Chapman, M. J. (2011). High-density lipoproteins: Structure, metabolism, function and therapeutics. John Wiley & Sons. https://doi.org/10.1002/9781118158678
Lee, Y.-M., Venkataraman, K., Hwang, S.-I., Han, D. K., & Hla, T. (2007). A novel method to quantify sphingosine 1-phosphate by immobilized metal affinity chromatography (IMAC). Prostaglandins & Other Lipid Mediators, 84(3), 154-162. https://doi.org/10.1016/j.prostaglandins.2007.08.001
Lepedda, A. J., Nieddu, G., Zinellu, E., De Muro, P., Piredda, F., Guarino, A., … Formato, M. (2013). Proteomic analysis of plasma-purified VLDL, LDL, and HDL fractions from atherosclerotic patients undergoing carotid endarterectomy: identification of serum amyloid A as a potential marker. Oxidative Medicine and Cellular Longevity, 2013, 1-11. https://doi.org/10.1155/2013/385214
Liu, Y., Sogawa, K., Sunaga, M., Umemura, H., Satoh, M., Kazami, T., … Nomura, F. (2014). Increased Concentrations of Apo AI and Apo A-II Fragments in the serum of patients with hepatocellular carcinoma by magnetic beads-assisted MALDI-TOF mass spectrometry. American Journal of Clinical Pathology, 141(1), 52-61. https://doi.org/10.1309/AJCPBLFBNAP6N2UN
Manjunatha, S., Distelmaier, K., Dasari, S., Carter, R. E., Kudva, Y. C., & Nair, K. S. (2016). Functional and proteomic alterations of plasma high density lipoproteins in type 1 diabetes mellitus. Metabolism, 65(9), 1421-1431.
Matheron, L., van den Toorn, H., Heck, A. J., & Mohammed, S. (2014). Characterization of biases in phosphopeptide enrichment by Ti4+-immobilized metal affinity chromatography and TiO2 using a massive synthetic library and human cell digests. Analytical Chemistry, 86(16), 8312-8320. https://doi.org/10.1021/ac501803z
May, H. T., Anderson, J. L., Winegar, D. A., Rollo, J., Connelly, M. A., Otvos, J. D., & Muhlestein, J. B. (2016). Utility of high density lipoprotein particle concentration in predicting future major adverse cardiovascular events among patients undergoing angiography. Clinical Biochemistry, 49(15), 1122-1126. https://doi.org/10.1016/j.clinbiochem.2016.09.004
Mohyuddin, A., Hussain, D., Fatima, B., Athar, M., Ashiq, M. N., & Najam-ul-Haq, M. (2019). Gallic acid functionalized UiO-66 for the recovery of ribosylated metabolites from human urine samples. Talanta, 201, 23-32. https://doi.org/10.1016/j.talanta.2019.03.072
Mouchard, A., Boutonnet, M.-C., Mazzocco, C., Biendon, N., Macrez, N., & Neuro, C. E. B. N. N. (2019). ApoE-fragment/Aβ heteromers in the brain of patients with Alzheimer's disease. Scientific Reports, 9(1), 3989. https://doi.org/10.1038/s41598-019-40438-4
Najam-ul-Haq, M., Jabeen, F., Shafiq, F., Sajid, S., & Saba, A. (2015). New cellulose-silica composite IMAC/C18 for the selective enrichment of phosphorylated molecules and the improved recovery of hydrophilic species. RSC Advances, 5(2), 1034-1042. https://doi.org/10.1039/C4RA10254A
Nicolardi, S., van der Burgt, Y. E., Dragan, I., Hensbergen, P. J., & Deelder, A. M. (2013). Identification of new apolipoprotein-CIII glycoforms with ultrahigh resolution MALDI-FTICR mass spectrometry of human sera. Journal of Proteome Research, 12(5), 2260-2268. https://doi.org/10.1021/pr400136p
Peano, C., Wolf, J., Demol, J., Rossi, E., Petiti, L., De Bellis, G., … Landini, P. (2015). Characterization of the Escherichia coli σ S core regulon by chromatin immunoprecipitation-sequencing (ChIP-seq) analysis. Scientific Reports, 5, 10469. https://doi.org/10.1038/srep10469
Rye, K.-A. (2014). Biomarkers associated with high-density lipoproteins in atherosclerotic kidney disease. Clinical and Experimental Nephrology, 18(2), 247-250. https://doi.org/10.1007/s10157-013-0865-x
Saeed, A., Hussain, D., Saleem, S., Mehdi, S., Javeed, R., Jabeen, F., & Najam-ul-Haq, M. (2019). Metal-organic framework-based affinity materials in proteomics. Analytical and Bioanalytical Chemistry., 411, 1745-1759. https://doi.org/10.1007/s00216-019-01610-x
Schuchardt, M., Prüfer, N., Tu, Y., Herrmann, J., Hu, X.-P., Chebli, S., … Tölle, M. (2019). Dysfunctional high-density lipoprotein activates toll-like receptors via serum amyloid A in vascular smooth muscle cells. Scientific Reports, 9(1), 3421. https://doi.org/10.1038/s41598-019-39846-3
Shah, A. S., Tan, L., Long, J. L., & Davidson, W. S. (2013). Proteomic diversity of high density lipoproteins: Our emerging understanding of its importance in lipid transport and beyond. Journal of Lipid Research, 54(10), 2575-2585. https://doi.org/10.1194/jlr.R035725
Sun, H.-Y., Chen, S.-F., Lai, M.-D., Chang, T.-T., Chen, T.-L., Li, P.-Y., … Young, K.-C. (2010). Comparative proteomic profiling of plasma very-low-density and low-density lipoproteins. Clinica Chimica Acta, 411(5-6), 336-344. http://doi.org/10.1016/j.cca.2009.11.023
Van Hemelrijck, M., Walldius, G., Jungner, I., Hammar, N., Garmo, H., Binda, E., … Holmberg, L. (2011). Low levels of apolipoprotein AI and HDL are associated with risk of prostate cancer in the Swedish AMORIS study. Cancer Causes & Control, 22(7), 1011-1019. https://doi.org/10.1007/s10552-011-9774-z
Vaz, F. M., Pras-Raves, M., Bootsma, A. H., & van Kampen, A. H. (2015). Principles and practice of lipidomics. Journal of Inherited Metabolic Disease, 38(1), 41-52. https://doi.org/10.1007/s10545-014-9792-6
Wang, M., & Turko, I. V. (2013). Mass spectrometry quantification revealed accumulation of C-terminal fragment of apolipoprotein E in the Alzheimer's frontal cortex. PLoS ONE, 8(4), e61498. https://doi.org/10.1371/journal.pone.0061498
Wang, S.-T., Huang, W., Deng, Y.-F., Gao, Q., Yuan, B.-F., & Feng, Y.-Q. (2014). “Old” metal oxide affinity chromatography as “novel” strategy for specific capture of cis-diol-containing compounds. Journal of Chromatography a, 1361, 100-107. https://doi.org/10.1016/j.chroma.2014.07.091
Zhang, C., Rodriguez, E., Bi, C., Zheng, X., Suresh, D., Suh, K., … Hage, D. S. (2018). High performance affinity chromatography and related separation methods for the analysis of biological and pharmaceutical agents. Analyst, 143(2), 374-391. https://doi.org/10.1039/C7AN01469D
Zhu, G.-T., He, X.-M., Chen, X., Hussain, D., Ding, J., & Feng, Y.-Q. (2016). Magnetic graphitic carbon nitride anion exchanger for specific enrichment of phosphopeptides. Journal of Chromatography a, 1437, 137-144. https://doi.org/10.1016/j.chroma.2016.01.080
Zhu, L., Luu, T., Emfinger, C. H., Parks, B. A., Shi, J., Trefts, E., … Stafford, J. M. (2018). CETP inhibition improves HDL function but leads to fatty liver and insulin resistance in CETP-expressing transgenic mice on a high-fat diet. Diabetes, 67, 2494-2506. https://doi.org/10.2337/db18-0474