Phylogenetic analysis of West Nile virus in Quebec, Canada, 2004-2016: Co-circulation of distinct variants harbouring conserved amino acid motifs in North America.
Amino acid substitution
Arbovirus
Genome
Genotype
Mosquito vector
Mutation
Phylogenic analysis
West Nile virus
Journal
Virology
ISSN: 1096-0341
Titre abrégé: Virology
Pays: United States
ID NLM: 0110674
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
15
07
2019
revised:
16
08
2019
accepted:
19
08
2019
pubmed:
30
8
2019
medline:
12
6
2020
entrez:
30
8
2019
Statut:
ppublish
Résumé
West Nile virus (WNV) was introduced for the first time in the western hemisphere in 1999 in New York City. In 2002, a phenotype-modifying mutation (Env-V159A) defined the first North American genotype WN02. So far, three genotypes has been described in North America but little is known about WNV evolution in Canada. We report the phylogenetic characterization of twenty-six WNV genomes isolated from mosquitoes in the province of Quebec. WNV strains found in Quebec are phylogenetically related to American strains collected in northern and southern regions. We also noted the presence of two robust monophyletic groups of isolates characterized by distinct conserved amino acid motifs. These emerging genotypes were detected for several years in different ecosystems. These results highlight the need for the maintenance of a nationwide surveillance to follow the dispersion of emergent WNV genotypes.
Identifiants
pubmed: 31465892
pii: S0042-6822(19)30232-6
doi: 10.1016/j.virol.2019.08.019
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-73Informations de copyright
Crown Copyright © 2019. Published by Elsevier Inc. All rights reserved.